IP Library Granted Patent US 8,900,299
Granted Patent B2
US 8,900,299 · App. 12/551,528 · Granted Dec 2, 2014

Method in eye surgery

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Quick Facts
Patent No.
US 8,900,299
App. No.
12/551,528
Granted
Dec 2, 2014
Kind
B2
Abstract

A method for prevention of migration of epithelial cells in a capsular bag of an eye of a mammal is provided. The method comprises removing the natural lens of the eye from the capsular bag; introducing an object with at least one sharp edge into the capsular bag, in such a way that said sharp edge contacts the inside of the capsular bag to form a barrier preventing migration of epithelial cells across said barrier; and injecting a lens-forming composition into the capsular bag.

Claims (32)

1. Method for forming a lens in situ in an eye of a mammal, comprising:

removing the natural lens of the eye from the capsular bag;

introducing an optic with a radius and at least one sharp edge into the capsular bag and positioning the optic within the capsular bag with the at least one sharp edge contacting an inside wall of the capsular bag;

wherein the radius of the optic is large enough such that the optic will span a diameter of the capsular bag at approximately the equator so as to push the at least one sharp edge against the inside wall of the capsular bag at approximately the equator to create a barrier;

injecting a lens-forming composition into the capsular bag to fill the capsular bag; and

curing the lens-forming composition to form a lens having an outer circumference, wherein the formed lens completely fills the capsular bag and the at least one sharp edge remains in contact with an inside wall of the capsular bag after lens formation;

wherein the optic has optical properties that may be used in combination with optical properties of the injected lens-forming composition.

2. Method according to claim 1 , wherein the lens-forming composition comprises polysiloxane.

3. Method according to claim 2 , wherein the lens-forming composition comprising polysiloxane has a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens, and a viscosity suitable for injection of the composition through a standard cannula.

4. Method according to claim 2 , wherein the lens-forming composition comprises polysiloxane of a siloxane monomer unit —R a R b SiO—, wherein R a and R b are the same or different alkyl or phenyl groups, at least one of which is substituted with at least one fluorine atom.

5. Method according to claim 2 , wherein the lens-forming composition comprises polysiloxane that is a terpolymer or higher polymer of three or more different siloxane monomer units.

6. Method according to claim 2 , wherein the lens-forming composition comprises polysiloxane that is a terpolymer of (a) dimethylsiloxane, (b) methylphenylsiloxane or diphenylsiloxane, and (c) trifluoropropylmethylsiloxane monomers.

7. Method according to claim 2 , wherein the lens-forming composition comprises polysiloxane having crosslinkable groups, and further comprises a crosslinking agent and optionally an effective amount of a catalyst.

8. Method according to claim 1 , wherein the lens-forming composition comprises a hydrogel.

9. The method of claim 1 , further comprising pressing the inside wall of the capsular bag with enough pressure to prevent migration of epithelial cells.

10. The method of claim 1 , further comprising filling the capsular bag with the lens-forming composition and, after filling the capsular bag, putting the capsular bag under tension.

11. Method for forming a lens in situ in an eye of a mammal, comprising:

removing the natural lens of the eye from the capsular bag;

introducing an optic with a radius and at least one sharp edge along an outer circumference of the optic into the capsular bag and positioning the optic within the capsular bag, with the at least one sharp edge contacting an inside wall of the capsular bag;

wherein the radius of the optic is large enough such that the at least one sharp edge will push the inside wall of the capsular bag at approximately the equator to create a barrier;

injecting a lens-forming composition into the capsular bag to fill the capsular bag; and

curing the lens-forming composition to form a lens having an outer circumference, wherein the formed lens completely fills the capsular bag and the optic remains in the capsular bag, the at least one sharp edge remaining in contact with an inside wall of the capsular bag after lens formation by curing of the lens-forming composition;

wherein the optic has optical properties that may be used in combination with optical properties of the injected lens-forming composition.

12. The method of claim 11 , further comprising pressing the inside wall of the capsular bag with enough pressure to prevent migration of epithelial cells.

13. The method of claim 11 , further comprising filling the capsular bag with the lens-forming composition and, after filling the capsular bag, putting the capsular bag under tension.

14. Method according to claim 11 , wherein the lens-forming composition comprises polysiloxane.

15. Method according to claim 14 , wherein the lens-forming composition comprising polysiloxane has a specific gravity of greater than about 1.0, a refractive index suitable for restoring the refractive power of the natural crystalline lens, and a viscosity suitable for injection of the composition through a standard cannula.

16. Method according to claim 14 , wherein the lens-forming composition comprises polysiloxane of a siloxane monomer unit —R a R b SiO—, wherein R a and R b are the same or different alkyl or phenyl groups, at least one of which is substituted with at least one fluorine atom.

17. Method according to claim 14 , wherein the lens-forming composition comprises polysiloxane that is a terpolymer or higher polymer of three or more different siloxane monomer units.

18. Method according to claim 14 , wherein the lens-forming composition comprises polysiloxane that is a terpolymer of (a) dimethylsiloxane, (b) methylphenylsiloxane or diphenylsiloxane, and (c) trifluoropropylmethylsiloxane monomers.

19. Method according to claim 14 , wherein the lens-forming composition comprises polysiloxane having crosslinkable groups, and further comprises a crosslinking agent and optionally an effective amount of a catalyst.

20. Method according to claim 11 , wherein the lens-forming composition comprises a hydrogel.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 12, 2014
From: TERWEE, THOMAS
To: PHARMACIA GRONINGEN BV
Reel/Frame 033729/0548 →
CHANGE OF NAME Recorded Sep 12, 2014
From: PHARMACIA GRONINGEN BV
To: AMO GRONINGEN B.V.
Reel/Frame 033729/0638 →