Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity
View Patent ↗The invention provides hops ( Humulus lupulus ) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
1. A method of reducing gastric toxicity associated with a administration of a non-steroidal anti-inflammatory compound in a mammal, comprising administering to the mammal being treated with the non-steroidal anti-inflammatory compound a daily dose of about 0.5 to about 10,000 mg per day of a compound selected from the group consisting of dihydro-isohumulone, dihydro-isocohumulone, dihydro-isoadhumulone, tetrahydro-isohumulone, tetrahydro-isocohumulone, tetrahydro-isoadhumulone, hexahydro-isohumulone, hexahydro-isocohumulone, and hexahydro-isoadhumulone.
2. The method of claim 1 , wherein the compound is derived from hops.
3. The method of claim 1 , wherein the compound is administered at a daily dose of about 50 to about 7,500 mg per day.
4. The method of claim 1 , wherein the compound is administered with a pharmaceutically acceptable carrier.
5. The method of claim 1 , wherein the compound is administered orally, topically, parenterally, or rectally.