IP Library Granted Patent US 8,119,742
Granted Patent B2
US 8,119,742 · App. 12/568,542 · Granted Feb 21, 2012

Multi-armed catechol compound blends

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Quick Facts
Patent No.
US 8,119,742
App. No.
12/568,542
Granted
Feb 21, 2012
Kind
B2
Abstract

The invention describes families of compounds that utilize multihydroxyl phenyl groups to provide adhesive properties. Selection of the multihydroxy phenyl group along with linkers or linking groups and the linkages between the linkers or linking groups with polyalkylene oxides, provides materials that can be engineered to afford controllable curing time, biodegradation and/or swelling.

Claims (35)

1. A compound comprising formula (I):

wherein

each DHPD a , DHPD 1 , DHPD p , independently, can be the same or different;

each L b , L k , and L o , is

each L d , L i and L m represent a bond between the O and respective PA of the compound;

each PA c , PA j and PA n , independently, can be the same or different;

e is a value from 1 to about 3;

f is a value from 1 to about 10;

g is a value from 1 to about 3;

h is a value from 1 to about 10; wherein f+h is a value from 6 to about 20;

each of R 1 , R 2 and R 3 , independently, is a branched or unbranched alkyl group having at least 1 carbon atom;

each PA, independently, is a poly(alkylene oxide) polyether having a molecular weight between about 1,500 and about 5,000 daltons; and

each DHPD, independently, is a dopamine, 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenyl ethanol or 3,4-dihydroxyhydrocinnamic acid residue.

2. The compound of claim 1 , wherein each of PA c , PA j and PA n is a polyethylene glycol polyether.

3. The compound of claim 1 , wherein each of L b , L k , and L o are amide linkages and L d , L i and L m represent ether bonds.

4. The compound of claim 1 , wherein e and g each have a value of 1 and f is 4 or 6.

5. The compound of claim 1 , wherein h is 1.

6. The compound of claim 1 , wherein each of DHPD a , DHPD 1 , DHPD p is a dopamine residue;

each of L d , L i and L m represent ether bonds;

each of PA c , PA j and PA n are polyethylene glycol polyether derivatives comprising a hydroxyl terminal residue, each having a molecular weight of between about 1,500 and about 5,000 daltons;

e is 1;

f is 1;

g is 1; and

h is 6.

7. A compound comprising formula (I):

wherein

each of DHPD a , DHPD l , DHPD p is a dopamine residue;

each of the linkers, L b , L k , and L o , form an amide linkage between the dopamine residue and one terminal portion of a dicarboxylic acid residue and an ester between the second terminal portion of the dicarboxylic acid residue and the terminal portion of the polyethylene glycol polyether;

each L b , L k , and L o , independently, can be the same or different;

each of L d , L i and L m represent ether bonds;

each of PA c , PA j and PA n are polyethylene glycol polyether derivatives comprising a hydroxyl terminal residue, each having a molecular weight of between about 1,500 and about 3,500 daltons;

each PA c , PA j and PA n , independently, can be the same or different;

wherein e, f and g each have a value of 1; and

h is 6.

8. The compound of claim 7 , wherein each of the linkers L b , L k , and Lo, independently, can be the same or different, and is selected from the group consisting of

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2018
From: KENSEY NASH CORP.
To: DSM IP ASSETS B.V.
Reel/Frame 044985/0395 →
MERGER Recorded Mar 10, 2014
From: KNC NER ACQUISITION SUB, INC.
To: KENSEY NASH CORPORATION
Reel/Frame 032394/0645 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2011
From: NERITES CORPORATION
To: KNC NER ACQUISITION SUB, INC.
Reel/Frame 026355/0762 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 25, 2011
From: NERITES CORPORATION
To: KNC NER ACQUISITION SUB, INC.
Reel/Frame 026108/0921 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 19, 2010
From: DALSIN, JEFFREY L.; LEE, BRUCE P.; VOLLENWEIDER, LAURA; SILVARY, SUNIL; MURPHY, JOHN L.; XU, FANGMIN; SPITZ, AMANDA; LYMAN, ARINNE
To: NERITES CORPORATION
Reel/Frame 024108/0136 →