Article Containing Segregated Biguanide and Lewis Acid

1 . A medical device comprising:

a first region comprising a biguanide or a pharmaceutically acceptable salt thereof; and

a second region comprising a Lewis acid.

2 . The medical device according to claim 1 , wherein the biguanide is an Alexidine.

3 . The medical device according to claim 1 , wherein the biguanide is a chlorhexidine.

4 . The medical device according to claim 1 , wherein the biguanide is a polyhexamethyl biguanide (PHMB).

5 . The medical device according to claim 1 , wherein the biguanide includes a mixture of a plurality of biguanide agents.

6 . The medical device according to claim 1 , wherein the Lewis acid is a triarylmethane.

7 . The medical device according to claim 6 , wherein the triarylmethane includes brilliant green.

8 . The medical device according to claim 6 , wherein the Lewis acid includes a methyl violet.

9 . The medical device according to claim 8 , wherein the methyl violet is gentian violet.

10 . The medical device according to claim 1 , wherein the Lewis acid is a methyl donor.

11 . The medical device according to claim 1 , wherein the Lewis acid includes a mixture of a plurality of Lewis acids.

12 . The medical device according to claim 1 , wherein the first region is a first layer.

13 . The medical device according to claim 12 , wherein the second region is a second layer.

14 . The medical device according to claim 13 , wherein the first region and second region are co-extruded.

15 . The medical device according to claim 14 , further comprising:

a third layer disposed between the first layer and second layer.

16 . The medical device according to claim 1 , further comprising:

a multitude of first regions encapsulated in the medical device; and

a multitude of second regions encapsulated in the medical device.

17 . The medical device according to claim 16 , wherein the multitude of first regions and the multitude of second regions are microspheres.

18 . The medical device according to claim 1 , wherein the first region is a first stripe disposed longitudinally along the medical device.

19 . The medical device according to claim 18 , wherein the second region is a second stripe disposed longitudinally adjacent to the first stripe.

20 . The medical device according to claim 1 , wherein the medical device is a catheter, tube, suture, non-woven material, mesh, drain, shunt, or stent.

21 . A method of making an infection resistant medical article, the method comprising steps of:

generating a first region comprising a biguanide or a pharmaceutically acceptable salt thereof; and

generating a second region comprising a Lewis acid.

22 . The method according to claim 21 , further comprising the step of:

selecting an Alexidine as the biguanide.

23 . The method according to claim 21 , further comprising the step of:

selecting a chlorhexidine as the biguanide.

24 . The method according to claim 21 , further comprising the step of:

selecting a polyhexamethyl biguanide (PHMB) as the biguanide.

25 . The method according to claim 21 , further comprising the step of:

selecting a mixture of a plurality of biguanides as the biguanide.

26 . The method according to claim 21 , further comprising the step of:

selecting a triarylmethane as the Lewis acid.

27 . The method according to claim 26 , further comprising the step of:

selecting a brilliant green as the triarylmethane.

28 . The method according to claim 26 , further comprising the step of:

selecting a methyl violet as the Lewis acid.

29 . The method according to claim 28 , further comprising the step of:

selecting a gentian violet as the methyl violet.

30 . The method according to claim 21 , further comprising the step of:

selecting a methyl donor as the Lewis acid.

31 . The method according to claim 21 , further comprising the step of:

selecting a mixture of a plurality of Lewis acids as the Lewis acid.

32 . The method according to claim 21 , further comprising the step of:

generating a first layer as the first region.

33 . The method according to claim 32 , further comprising the step of:

generating a second layer as the second region.

34 . The method according to claim 33 , further comprising the step of:

co-extruding the first region and second region.

35 . The method according to claim 34 , further comprising the step of:

co-extruding a third layer disposed between the first layer and second layer.

36 . The method according to claim 21 , further comprising the steps of:

encapsulating a multitude of first regions in the medical device; and

encapsulating a multitude of second regions in the medical device.

37 . The method according to claim 36 , further comprising the steps of:

generating a first multitude of microspheres including the biguanide; and

generating a second multitude of microspheres including the Lewis acid.

38 . The method according to claim 35 , further comprising the step of:

co-extruding a first stripe disposed longitudinally along the medical device.

39 . The method according to claim 38 , further comprising the step of:

co-extruding a second stripe disposed longitudinally adjacent to the first stripe.

40 . The method according to claim 21 , further comprising the step of:

fabricating a catheter, tube, suture, non-woven material, mesh, drain, shunt, or stent with the first region and second region.

41 . A medical device comprising:

a first region comprising a chlorhexidine or a pharmaceutically acceptable salt thereof;

a second region comprising a gentian violet; and

a third region disposed between the first region and the second region to separate the first region from the second region.