IP Library Granted Patent US 8,715,654
Granted Patent B2
US 8,715,654 · App. 12/572,445 · Granted May 6, 2014

Methods of modulating the negative chemotaxis of immune cells

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Quick Facts
Patent No.
US 8,715,654
App. No.
12/572,445
Granted
May 6, 2014
Kind
B2
Abstract

The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.

Claims (2)

1. A method of inducing migration of an immune cell toward an ovarian cancer cell comprising inhibiting the activity of a chemorepellant release from the cancer cell, wherein the migration of the immune cell is induced in a patient suffering from ovarian cancer, and wherein the inhibition of the chemorepellant is carried out by the administration of an antibody which binds to apolipoprotein A1.

2. A method of inducing negative chemotaxis of a neutrophil in a patient in need thereof comprising administering apolipoprotein A1 to said patient in an amount effective to induce negative chemotaxis of the neutrophil, wherein the patient is suffering from an inflammatory condition, wherein the apolipoprotein A1 is administered locally, and wherein the inflammatory condition is selected from the group consisting of injection site reaction, Behcet's syndrome, synovitis, gout, fasciitis, arthritides, uveitis, burns, dermatitis, dermatomyositis, urticaria, acne, adult respiratory distress syndrome, bronchitis, emphysema, rhinitis, cystic fibrosis, pneumonitis, pneumoultramicroscopic silicovolcanoconiosis, alveolitis, bronchiolitis, pharyngitis, pleurisy, sinusitis, chronic obstructive pulmonary disease, acute lung injury, and hay fever.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2020
From: CELTAXSYS, INC.
To: CELLTAXIS, LLC
Reel/Frame 052665/0107 →
SECURITY INTEREST Recorded Oct 9, 2019
From: CELTAXSYS, INC.
To: DOMAIN PARTNERS VIII, L.P.; MASTERS, MICHAEL W.; INVUS PUBLIC EQUITIES, L.P.; LUMIRA CAPITAL II, L.P.; LUMIRA CAPITAL II (INTERNATIONAL), L.P.; GRA VENTURE FUND, LLC; GRA VENTURE FUND (T.E.), LLC; JWR, JR. FAMILY TRUST; ROGERS, JOE W., JR.; JOHNSON, WYATT THOMAS; 2007 STARR MOORE REVOCABLE TRUST
Reel/Frame 050666/0464 →
SECURITY INTEREST Recorded Sep 24, 2019
From: CELTAXSYS, INC.
To: DOMAIN PARTNERS VIII, L.P.; MASTERS, MICHAEL W.; MASTERS CAPITAL MANAGEMENT, LLC; MASTERS CAPITAL HEALTH VENTURES, LLC; INVUS PUBLIC EQUITIES, L.P.; LUMIRA CAPITAL II, L.P.; LUMIRA CAPITAL II (INTERNATIONAL), L.P.; GRA VENTURE FUND, LLC; GRA VENTURE FUND (T.E.), LLC; JWR, JR. FAMILY TRUST; ROGERS, JOE W., JR.; JOHNSON, WYATT THOMAS; 2007 STARR MOORE REVOCABLE TRUST
Reel/Frame 050469/0631 →
SECURITY INTEREST Recorded Nov 30, 2018
From: CELTAXSYS, INC.
To: DOMAIN PARTNERS VIII, L.P.; MASTERS, MICHAEL W.; MASTERS CAPITAL MANAGEMENT, LLC; MASTERS CAPITAL HEALTH VENTURES, LLC; INVUS PUBLIC EQUITIES, L.P.; LUMIRA CAPITAL II, L.P.; LUMIRA CAPITAL II (INTERNATIONAL), L.P.; GRA VENTURE FUND, LLC; GRA VENTURE FUND (T.E.), LLC; JWR, JR. FAMILY TRUST; ROGERS, JOE W., JR.; JOHNSON, WYATT THOMAS; 2007 STARR MOORE REVOCABLE TRUST
Reel/Frame 048172/0648 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 22, 2009
From: CHAVAN, SURENDRA; MOON, JONATHAN L.; BHATT, LOPA
To: CELTAXSYS, INC.
Reel/Frame 023692/0311 →