Benzimidazole anthelmintic compositions
View Patent ↗The present invention provides a veterinary anthelmintic composition that includes: at least 10% w/v of a benzimidazole anthlemintic; and b) a water-immiscible solvent system, which comprises a lactone solvent, an essential oil, and surfactant.
1. A self-emulsifying, pour-on, veterinary anthelmintic composition comprising: a) 15 to 25% w/v of triclabendazole; and b) a water-immiscible solvent system, which comprises a lactone solvent in an amount of about 10% to about 40% w/v, wherein said lactone solvent is γ-hexalactone; an essential oil in an amount of about 29% w/v, and surfactant in an amount of about 30% to about 60% w/v, wherein the surfactant is selected from PEG-8 caprylic/capric glycerides or PEG-6 caprylic/capric glycerides.
2. The composition of claim 1 , wherein the triclabendazole is present in an amount of about 20% w/v.
3. The composition of claim 1 , wherein the essential oil component is 1,8-cineole.
4. The composition of claim 1 , wherein the surfactant is PEG-8 caprylic/capric glycerides.
5. The composition of claim 1 , which includes at least one additional anthelmintic selected from a the group consisting of macrocyclic lactone.
6. The composition of claim 5 , wherein the macrocyclic lactone is moxidectin.
7. A self-emulsifying, pour-on, veterinary anthelmintic composition, comprising: about 15% to about 25% w/v of triclabendazole; and b) a water immiscible solvent system, which comprises γ-hexalactone in an amount of about 10% to about 40% w/v, 1,8-cineole in an amount of about 10% to about 35% w/v, and PEG-8 caprylic/capric glycerides in an amount of about 30% to about 60% w/v.
8. The composition of claim 7 , further comprising moxidectin.
9. The composition of claim 8 , wherein the moxidectin is present in an amount of about 0.01 to about 2% w/v.
10. A method of treating parasites in a homeothermic animal, said method comprising administering to said animal a self-emulsifying, pour-on, veterinary anthelmintic composition comprising: a) about 15% to about 25% w/v of triclabendazole, and b) a water-immiscible solvent system, which comprises γ-hexalactone in an amount of about 10% to about 40% w/v, about 10% to about 35% w/v of the essential oil, 1,8-cineole, and surfactant in an amount of about 30% to about 60% w/v, wherein the surfactant is PEG-8 caprylic/capric glycerides or PEG-6 caprylic/capric glycerides, and wherein said composition further comprises moxidexctin in an amount of about 0.01 to about 2% w/v.
11. The method of claim 10 , wherein the triclabendazole is present in an amount of about 20% w/v, and wherein the surfactant is PEG-8 caprylic/capric glycerides.
12. A self-emulsifying, pour-on, veterinary anthelmintic composition comprising: a) 20% triclabendazole, and b) a water-immiscible solvent system, which comprises a γ-hexalactone in an amount of about 14% w/v, 1,8-cineole in an amount of about 29% w/v, and PEG-8 caprylic/caprylate as a surfactant in an amount of about 36% w/v.