Stable solutions of orlistat for pharmaceutical dosage forms
View Patent ↗Liquid orlistat-containing fill materials suitable for encapsulating in hard or soft capsules are described herein. The fill material contains orlistat dissolved in one or more medium chain triglycerides or medium chain partial triglycerides, one or more citrate esters, and combinations thereof. The fill material can also contain one or more pharmaceutically acceptable excipients. In one embodiment, the fill material is substantially free of surfactants. The fill material can be encapsulated in hard or soft, gelatin or non-gelatin capsules. The capsules may be coated to modify release of orlistat from the capsule. Alternatively, the fill material can be encapsulated in an enteric capsule, wherein the enteric polymer is a component of the capsule shell, rather than a coating over the capsule shell. The fill materials are stable at elevated temperatures over an extended period of time and allow for high loadings of orlistat (e.g., 20% w/w or higher).
1. A soft or hard capsule comprising a liquid fill material comprising orlistat and a pharmaceutically acceptable carrier, wherein the carrier is selected from the group consisting of one or more medium chain triglycerides or partial triglycerides which are liquids at about −5° C., one or more C 1 -C 10 esters of citric acid, and combinations thereof.
2. The capsule of claim 1 , wherein the one or more medium chain triglycerides or partial triglycerides comprise C 2 -C 12 alkyl chains.
3. The capsule of claim 2 , wherein the one or more medium chain triglycerides or partial triglycerides comprise C 8 -C 10 alkyl chains.
4. The capsule of claim 2 , wherein the one or more medium chain triglycerides or partial triglycerides are selected from the group consisting of caprylic and capric triglycerides, and combinations thereof.
5. The capsule of claim 4 , wherein the medium chain triglyceride is a caprylic and capric triglyceride.
6. The capsule of claim 1 , wherein the one or more C 1 -C 10 esters of citric acid are selected from the group consisting of triethylcitrate, acetyltributyl citrate, acetyltriethyl citrate, tributyl citrate, and combinations thereof.
7. The capsule of claim 1 , wherein the fill material is substantially free of surfactant.
8. The capsule of claim 1 , wherein the fill material further comprises an antioxidant.
9. The capsule of claim 8 , wherein the antioxidant is selected from the group consisting of butylated hydroxyanisole (BHA); ascorbic acid, its salts and esters; Vitamin E, tocopherol and its salts; sodium metabisulphite; propyl gallate; and butylated hydroxytoluene (BHT).
10. The capsule of claim 1 , wherein the percent loading of orlistat is from about 5% to about 45% by weight of the fill material.
11. The capsule of claim 10 , wherein the percent loading of orlistat is from about 5% to about 30% by weight of the fill material.
12. The capsule of claim 10 , wherein the percent loading of orlistat is from about 5% to about 20% by weight of the fill material.
13. The capsule of claim 1 , wherein the percent degradation of orlistat is less than 10% when the capsule is heated at 65° C. for 7 days.
14. The capsule of claim 13 , wherein the percent degradation of orlistat is less than 5% when the capsule is heated at 65° C. for 7 days.
15. The capsule of claim 13 , wherein the percent degradation of orlistat is less than 1% when the capsule is heated at 65° C. for 7 days.
16. The capsule of claim 1 , wherein the capsule is a soft capsule.
17. The capsule of claim 16 , wherein the capsule is a soft gelatin capsule.
18. The capsule of claim 17 , wherein the soft gelatin capsule is an enteric capsule containing an acid insoluble polymer in the capsule shell.
19. The capsule of claim 1 , wherein the capsule is a hard capsule.
20. The capsule of claim 19 , wherein the capsule is a hard gelatin capsule.
21. A method of making the capsule of claim 1 , comprising dissolving orlistat in the carrier to form a solution and encapsulating the solution in a soft or hard capsule.
22. A method for treating obesity comprising administering to a subject in need thereof the capsule of claim 1 .
23. The capsule of claim 7 , wherein the fill material contains less than 0.1% surfactant.
24. The capsule of claim 7 , wherein the fill materials contains no surfactant.