IL-B30 antibodies
View Patent ↗Purified genes encoding cytokine referred to as interleukin-B30 (IL-B30) from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.
1. A recombinant antibody, or antigen binding fragment thereof, that specifically binds to a polypeptide comprising residues 1-168 of SEQ ID NO: 2.
2. The recombinant antibody, or antigen binding fragment thereof, of claim 1 wherein said antibody specifically binds to a polypeptide consisting of residues 1-168 of SEQ ID NO: 2.
3. The recombinant antibody, or antigen binding fragment thereof, of claim 1 comprising a full length antibody.
4. The recombinant antibody, or antigen binding fragment thereof, of claim 1 comprising:
a) a Fab fragment;
b) a Fab 2 fragment; or
c) a single chain antibody.
5. The recombinant antibody, or antigen binding fragment thereof, of claim 1 wherein the antibody or fragment binds said polypeptide with an affinity of at least 3 nM.
6. The recombinant antibody, or antigen binding fragment thereof, of claim 1 wherein said antibody is a monoclonal antibody.
7. The recombinant antibody, or antigen binding fragment thereof, of claim 1 wherein said antibody is a chimeric or humanized antibody.
8. A sterile composition comprising the recombinant antibody, or antigen binding fragment thereof, of claim 1 .
9. A pharmaceutical formulation comprising:
a) the recombinant antibody, or antigen binding fragment thereof, of claim 1 ; and
b) one or more pharmaceutically acceptable carriers.
10. A pharmaceutical formulation comprising:
a) the recombinant antibody, or antigen binding fragment thereof, of claim 2 ; and
b) one or more pharmaceutically acceptable carriers.