Methods for diagnosing ovarian cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. The biomarkers can be detected by SELDI mass spectrometry, immunoassay, or other means.
1. A method for qualifying ovarian cancer status in a subject comprising:
(a) measuring at least one biomarker in ovarian cyst fluid, serum, plasma, blood, or urine from the subject, wherein the at least one biomarker is Protein C inhibitor;
(b) comparing the measurement with a diagnostic amount that distinguishes a positive ovarian cancer status from a negative ovarian cancer status; and
(c) correlating the comparison with ovarian cancer status, wherein the ovarian cancer status is the presence or absence of ovarian cancer.
2. A method for diagnosing ovarian cancer in a subject, the method comprising:
(a) measuring at least one biomarker in ovarian cyst fluid, serum, plasma, blood, or urine from the subject, wherein the biomarker is Protein C inhibitor;
(b) comparing the measurement with a diagnostic amount that distinguishes a positive ovarian cancer status from a negative ovarian cancer status; and
(c) correlating the comparison with the presence or absence of ovarian cancer.