Frozen compositions and methods for piercing a substrate
Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
1 . A frozen piercing implement, comprising:
at least one sterile frozen non-hydrogen oxide solvent and at least one agent;
wherein the frozen piercing implement is configured for piercing at least one substrate; and
wherein the frozen piercing implement is substantially solid at approximately 65° C., approximately 60° C., approximately 55° C., approximately 50° C., approximately 45° C., approximately 40° C., approximately 37° C., approximately 35° C., approximately 30° C., approximately 25° C., approximately 20° C., approximately 15° C., approximately 10° C., approximately 5° C., approximately 0° C., approximately −5° C., approximately −10° C., approximately −15° C., approximately −20° C., approximately −25° C., approximately −30° C., approximately −40° C., approximately −50° C., approximately −60° C., approximately −70° C., approximately −80° C., approximately −90° C., approximately −100° C., approximately −120° C., approximately −150° C., approximately −170° C., approximately −200° C., approximately −250° C., or any temperature therebetween.
2 - 8 . (canceled)
9 . The frozen piercing implement of claim 1 , wherein the at least one agent includes at least one of a therapeutic agent, explosive material, reinforcement agent, adhesive agent, biological remodeling agent, or abrasive.
10 - 16 . (canceled)
17 . The frozen piercing implement of claim 1 , wherein the at least one agent includes one or more components that are inactive.
18 . The frozen piercing implement of claim 17 , wherein the one or more components are configured to be activated by administration.
19 . The frozen particle composition of claim 1 , wherein the at least one agent includes one or more of a prodrug or precursor compound.
20 - 25 . (canceled)
26 . The frozen piercing implement of claim 1 , further comprising at least one detection material.
27 . The frozen piercing implement of claim 26 , wherein the at least one detection material includes at least one of a contrast agent, sensor, or electronic identification device.
28 . The frozen piercing implement of claim 27 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
29 . The frozen piercing implement of claim 26 , wherein the at least one detection material includes at least one temperature-sensitive substance.
30 . The frozen piercing implement of claim 26 , wherein the at least one detection material includes at least one of a radioactive, luminescent, colorimetric or odorous substance.
31 - 32 . (canceled)
33 . The frozen piercing implement of claim 1 , wherein the at least one frozen piercing implement includes at least one channel.
34 - 41 . (canceled)
42 . The frozen piercing implement of claim 33 , wherein at least one surface of the at least one channel is substantially hydrophobic.
43 . The frozen piercing implement of claim 33 , wherein at least one surface of the at least one channel is substantially hydrophilic.
44 - 65 . (canceled)
66 . The frozen piercing implement of claim 1 , further including at least one non-frozen implement holding device.
67 . The frozen piercing implement of claim 66 , wherein the at least one non-frozen implement holding device includes at least one handle, robotic arm, or surgical device.
68 - 82 . (canceled)
83 . The frozen piercing implement of claim 1 , wherein the frozen piercing implement includes at least one port.
84 . The frozen piercing implement of claim 83 , wherein the at least one port includes at least one side port.
85 . The frozen piercing implement of claim 83 , wherein the at least one port includes at least one end port.
86 . The frozen piercing implement of claim 83 , wherein the at least one port includes at least one inlet port or outlet port.
87 . The frozen piercing implement of claim 83 , wherein the at least one inlet port or outlet port is in fluid communication with at least one channel.
88 - 90 . (canceled)
91 . The frozen piercing implement of claim 1 , formulated to be administered to the at least one substrate.
92 . The frozen piercing implement of claim 1 , wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, device, or food product.
93 - 96 . (canceled)
97 . The frozen piercing implement of claim 1 , wherein the at least one frozen piercing implement includes at least one sensor.
98 . The frozen piercing implement of claim 97 , wherein the at least one sensor includes at least one sensor configured for detecting at least one of a biochemical, electrical, optical, functional, physical, chemical, biological, or structural characteristic of the at least one material.
99 - 103 . (canceled)
104 . The frozen piercing implement of claim 1 , further comprising a plurality of frozen piercing implements.
105 . The frozen piercing implement of claim 1 , wherein the frozen piercing implement is included in at least one frozen piercing implement device.
106 . The frozen piercing implement of claim 105 , wherein the at least one frozen piercing implement device includes at least one of a frozen piercing implement array device, frozen piercing implement fluidic device, or frozen piercing implement injection device.
107 - 118 . (canceled)
119 . A frozen piercing implement, comprising:
at least one frozen agent;
wherein the frozen piercing implement is configured for piercing at least one substrate wherein the frozen piercing implement is substantially solid at approximately 65° C., approximately 60° C., approximately 55° C., approximately 50° C., approximately 45° C., approximately 40° C., approximately 37° C., approximately 35° C., approximately 30° C., approximately 25° C., approximately 20° C., approximately 15° C., approximately 10° C., approximately 5° C., approximately 0° C., approximately −5° C., approximately −10° C., approximately −15° C., approximately −20° C., approximately −25° C., approximately −30° C., approximately −40° C., approximately −50° C., approximately −60° C., approximately −70° C., approximately −80° C., approximately −90° C., approximately −100° C., approximately −120° C., approximately −150° C., approximately −170° C., approximately −200° C., approximately −250° C., or any temperature therebetween.
120 - 233 . (canceled)
234 . A method of administering at least one frozen piercing implement to at least one substrate, comprising:
contacting at least one substrate with at least one frozen piercing implement, wherein the at least one frozen piercing implement includes at least one sterile non-hydrogen oxide frozen solvent and at least one agent; and
wherein the at least one frozen piercing implement is substantially solid at approximately 65° C., approximately 60° C., approximately 55° C., approximately 50° C., approximately 45° C., approximately 40° C., approximately 37° C., approximately 35° C., approximately 30° C., approximately 25° C., approximately 20° C., approximately 15° C., approximately 10° C., approximately 5° C., approximately 0° C., approximately −5° C., approximately −10° C., approximately −15° C., approximately −20° C., approximately −25° C., approximately −30° C., approximately −40° C., approximately −50° C., approximately −60° C., approximately −70° C., approximately −80° C., approximately −90° C., approximately −100° C., approximately −120° C., approximately −150° C., approximately −170° C., approximately −200° C., approximately −250° C., or any temperature therebetween.
235 - 244 . (canceled)
245 . The method of claim 234 , wherein the at least one substrate includes one or more of a cell, tissue, organ, structure, device, or food product.
246 . The method of claim 245 , wherein the structure includes one or more of a prosthesis, cell scaffold, or tissue scaffold.
247 . The method of claim 245 , wherein the device includes at least one mechanical or electrical device.
248 . The method of claim 234 , wherein the substrate includes at least a portion of which is naturally, artificially, or synthetically derived.
249 . The method of claim 234 , wherein the substrate includes at least a portion of which is genetically altered.
250 . The method of claim 234 , wherein the at least one substrate is located in at least one of in situ, in vitro, in vivo, in utero, in planta, in silico, or ex vivo.
251 - 256 . (canceled)
257 . The method of claim 234 , wherein the at least one substrate includes one or more of a stalk, stem, leaf, root, plant, or tendril.
258 - 261 . (canceled)
262 . The method of claim 234 , wherein the at least one substrate includes at least one cell mass.
263 . The method of claim 234 , wherein the at least one substrate includes one or more wounds.
264 . The method of claim 234 , wherein the at least one substrate includes at least a portion of at least one subject.
265 . The method of claim 234 , wherein the administering at least one frozen piercing implement includes self-administering the at least one frozen piercing implement by the at least one subject.
266 - 268 . (canceled)
269 . The method of claim 234 , wherein administering the at least one frozen piercing implement to at least one substrate includes accelerating, propelling, pushing, pulling, or ejecting the at least one frozen piercing implement toward the at least one substrate.
270 - 272 . (canceled)
273 . The method of claim 234 , further comprising varying the rate, velocity, force, or angle at which the at least one frozen piercing implement is administered to the at least one substrate.
274 - 278 . (canceled)
279 . The method of claim 234 , further comprising administering to the at least one substrate at least one article including an optical, photonic, or electronic article.
280 . The method of claim 279 , wherein the at least one article is configured to communicate with at least one computer system.
281 . The method of claim 279 , wherein the at least one article is configured to monitor at least one characteristic of the at least one substrate.
282 - 283 . (canceled)
284 . The method of claim 279 , wherein the at least one article includes at least one electronic identification device.
285 . The method of claim 284 , wherein the at least one electronic identification device includes at least one radio frequency identification device.
286 - 290 . (canceled)
291 . The method of claim 234 , further comprising sensing or extracting at least one material from the at least one substrate.
292 - 295 . (canceled)
296 . The method of claim 234 , further comprising withdrawing the at least one frozen piercing implement from the at least one substrate.
297 . A method of administering at least one frozen piercing implement to at least one substrate, comprising:
contacting at least one substrate with at least one frozen piercing implement, wherein the at least one frozen piercing implement includes at least one frozen agent; and
wherein the at least one frozen piercing implement is substantially solid at approximately 65° C., approximately 60° C., approximately 55° C., approximately 50° C., approximately 45° C., approximately 40° C., approximately 37° C., approximately 35° C., approximately 30° C., approximately 25° C., approximately 20° C., approximately 15° C., approximately 10° C., approximately 5° C., approximately 0° C., approximately −5° C., approximately −10° C., approximately −15° C., approximately −20° C., approximately −25° C., approximately −30° C., approximately −40° C., approximately −50° C., approximately −60° C., approximately −70° C., approximately −80° C., approximately −90° C., approximately −100° C., approximately −120° C., approximately −150° C., approximately −170° C., approximately −200° C., approximately −250° C., or any temperature therebetween.
298 - 313 . (canceled)