Systems for genome selection
View Patent ↗Systems, methods, compositions and apparatus relating to genome selection are disclosed.
1. An apparatus comprising:
one or more sourcing units including one or more first sources of one or more male germ line haploid genomes and one or more second sources of one or more probes;
one or more hybridization units operable to co-localize one or more of the one or more probes with one or more nucleic acids of the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more of the one or more probes hybridized to the one or more nucleic acids of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
2. The apparatus of claim 1 , further comprising:
one or more computing units operable to determine one or more genetic characteristics of the one or more male germ line haploid genomes.
3. The apparatus of claim 2 , wherein one or more computing units operable to determine one or more genetic characteristics of the one or more male germ line haploid genomes comprises:
one or more computing units operable to determine one or more of the one or more genetic characteristics of the one or more male germ line haploid genomes at least partially based on detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
4. The apparatus of claim 2 , wherein one or more computing units operable to determine one or more genetic characteristics of the one or more male germ line haploid genomes comprises:
one or more computing units operable to determine one or more of the one or more genetic characteristics of the one or more male germ line haploid genomes at least partially based on identification of one or more of the one or more probes hybridized to the one or more nucleic acids.
5. The apparatus of claim 2 , wherein the one or more computing units are operable to determine the one or more male germ line haploid genomes to select at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes.
6. The apparatus of claim 2 , wherein the one or more computing units are operable to determine the one or more male germ line haploid genomes to select at least partially based on a weighted analysis of the one or more genetic characteristics of the one or more male germ line haploid genomes.
7. The apparatus of claim 2 , wherein the one or more computing units are operable to determine the one or more male germ line haploid genomes to select at least partially based on one or more target genetic characteristics.
8. The apparatus of claim 2 , wherein the one or more computing units are operable to determine the one or more male germ line haploid genomes to select at least partially based on one or more genetic characteristics of one or more female germ line genomes.
9. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes.
10. The apparatus of claim 1 , wherein the one or more first sources of the one or more male germ line haploid genomes are positioned to provide the one or more male germ line haploid genomes to one or more first locations; and
the one or more second sources of the one or more probes are positioned to provide the one or more probes to one or more second locations.
11. The apparatus of claim 10 , wherein the one or more first locations are the same as the one or more second locations.
12. The apparatus of claim 10 , wherein the one or more first locations and the one or more second locations are included in the one or more hybridization units.
13. The apparatus of claim 1 , wherein the one or more controller units are operable to provide one or more of the one or more male germ line haploid genomes and one or more of the one or more probes to one or more first locations.
14. The apparatus of claim 1 , wherein the one or more controller units are operable to provide one or more of the one or more male germ line haploid genomes and one or more of the one or more probes to the one or more hybridization units.
15. The apparatus of claim 1 , wherein one or more of the one or more monitoring units are operable to identify one or more of the one or more probes hybridized to the one or more nucleic acids.
16. The apparatus of claim 1 , wherein one or more of the one or more hybridization units are operable to hybridize one or more of the one or more probes with one or more of the one or more male germ line haploid genomes.
17. The apparatus of claim 1 , wherein one or more of the one or more controller units are operable to separate one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
18. The apparatus of claim 1 , wherein one or more of the one or more controller units are operable to sort one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
19. The apparatus of claim 1 , wherein the one or more male germ line haploid genomes are at least partially isolated from one or more spermatozoa.
20. The apparatus of claim 1 , wherein the one or more male germ line haploid genomes are part of one or more spermatozoa.
21. The apparatus of claim 1 , wherein the one or more male germ line haploid genomes are at least partially isolated from one or more spermatids.
22. The apparatus of claim 1 , wherein the one or more male germ line haploid genomes are part of one or more spermatids.
23. The apparatus of claim 1 , wherein the one or more male germ line haploid genomes are at least partially condensed.
24. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on one or more target genetic characteristics.
25. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on one or more genetic characteristics of one or more female germ line genomes.
26. The apparatus of claim 1 , wherein one or more sourcing units including one or more first sources of one or more male germ line haploid genomes and one or more second sources of one or more probes further comprise:
one or more third sources of one or more female germ line genomes.
27. The apparatus of claim 26 , wherein one or more third sources of one or more female germ line genomes comprise:
one or more third sources of the one or more female germ line genomes, the one or more third sources positioned to provide the one or more female germ line genomes to one or more third locations.
28. The apparatus of claim 26 , wherein one or more third sources of one or more female germ line genomes comprises:
one or more third sources of the one or more female germ line genomes, the one or more third sources positioned to provide the one or more female germ line genomes to the one or more hybridization units.
29. The apparatus of claim 26 , wherein the one or more hybridization units are operable to co-localize the one or more probes with the one or more nucleic acids of the one or more female germ line genomes.
30. The apparatus of claim 26 , wherein the one or more monitoring units are operable to detect one or more of the one or more probes hybridized to the one or more nucleic acids of the one or more female germ line genomes.
31. The apparatus of claim 30 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids of the one or more female germ line genomes.
32. An apparatus comprising:
a detecting unit operable to identify one or more genetic characteristics of one or more male germ line haploid genomes using one or more nucleic acid detecting molecules other than a polyamide or Hoechst;
a first sourcing unit containing one or more sources of one or more male germ line haploid genomes;
a second sourcing unit containing one or more sources of the one or more nucleic acid detecting molecules; and
a first controller unit operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes.
33. An apparatus comprising:
one or more characterization units operable to detect one or more probes hybridized to one or more nucleic acids of one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
34. The apparatus of claim 33 , wherein the one or more characterization units are further operable to co-localize the one or more probes with the one or more nucleic acids of the one or more male germ line haploid genomes.
35. The apparatus of claim 33 , further comprising:
one or more sourcing units including one or more first sources of the one or more male germ line haploid genomes and one or more second sources of the one or more probes.
36. An apparatus comprising:
one or more characterization units operable to detect one or more probes hybridized to one or more nucleic acid sequences of one or more male germ line haploid genomes; and
one or more computing units operable to determine the one or more male germ line haploid genomes to select at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acid sequences.
37. An apparatus comprising:
one or more sourcing units including one or more first sources of one or more male germ line haploid genomes and one or more second sources of one or more probes;
one or more hybridization units operable to co-localize one or more of the one or more probes with one or more nucleic acids of the one or more male germ line haploid genomes;
one or more monitoring units operable to detect hybridization of one or more of the one or more probes with one or more of the one or more nucleic acids of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the detection of the hybridization of one or more of the one or more probes with one or more of the one or more nucleic acids.
38. An apparatus comprising:
one or more first sources of one or more male germ line haploid genomes;
one or more second sources of one or more probes;
one or more monitors for detecting one or more of the one or more probes;
one or more units for hybridizing one or more of the one or more probes with one or more nucleic acids of the one or more male germ line haploid genomes; and
one or more controllers for selecting one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.
39. An apparatus comprising:
one or more sourcing units including one or more first sources of one or more male germ line haploid genomes and one or more second sources of one or more probes;
one or more hybridization units operable to co-localize one or more of the one or more probes with one or more nucleic acids of the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more of the one or more probes hybridized to the one or more nucleic acids of the one or more male germ line haploid genomes; and
one or more computing units operable to determine the one or more male germ line haploid genomes to select at least partially based on the detection of one or more of the one or more probes hybridized to the one or more nucleic acids.