Drug combination and its use in the treatment of muscle loss
View Patent ↗The present invention is a product comprising a β2 agonist and a progestin, as a combined preparation for separate, simultaneous or sequential use in the treatment or prevention of muscle loss. The present invention is also a β2 agonist selected from R,R-formoterol, indacaterol or ritodrine, for use in the treatment or prevention of muscle loss.
1. A method for the treatment of muscle loss in association with cancer cachexia, wherein said method comprises administering, separately concomitantly, simultaneously or sequentially, to a subject having muscle loss in association with cancer cachexia, a therapeutically effective amount of formoterol and megestrol, wherein said megestrol is administered orally at a dose of 160 mg/day to 1600 mg/day.
2. The method according to claim 1 , wherein the megestrol is the acetate salt.
3. The method according to claim 1 , wherein formoterol is R,R-formoterol.
4. The method according to claim 1 , wherein the formoterol and megestrol are administered orally.
5. The method according to claim 3 , wherein the R,R-formoterol and megestrol are administered orally.
6. The method according to claim 1 , wherein the subject is a human.