Pharmaceutical use of substituted amides
View Patent ↗The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydro-genase type 1 (11βHSD1) and the use of these compounds as pharmaceutical composi-tions, are described. Also a novel class of substituted amides, their use in therapy, phar-maceutical compositions comprising the compounds, as well as their use in the manufac-ture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11βHSD1 and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active gluco-corticoid is desirable.
1. A compound selected from the group consisting of:
N-cyclopropyl-4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-N-methyl-butyramide;
4-(2,4-dichloro-phenoxy)-N-ethyl-N-(5-hydroxy-adamantan-2-yl)-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-methyl-adamantan-2-yl)-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-N-isopropyl-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-methyl-adamantan-2-yl)-N-methyl-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-2,2-dimethyl-butyramide;
4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-2,2,N-trimethyl-butyramide;
and 4-(2,4-dichloro-phenoxy)-N-(5-hydroxy-methyl-adamantan-2-yl)-2,2-dimethyl-butyramide;
or a pharmaceutically acceptable salt thereof.
2. 4-(2,4-Dichloro-phenoxy)-N-(5-hydroxy-adamantan-2-yl)-butyramide, or a pharmaceutically acceptable salt thereof.
3. 4-(2,4-Dichloro-phenoxy)-N-(5-hydroxy-methyl-adamantan-2-yl)-butyramide, or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
5. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier or excipient.
6. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier or excipient.