IP Library › Granted Patent US 8,202,885

Granted Patent B2

US 8,202,885 · App. 12/597,817 · Granted Jun 19, 2012

Bridged six-membered ring compounds

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Quick Facts

Patent No.: US 8,202,885
App. No.: 12/597,817
Granted: Jun 19, 2012
Kind: B2

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Abstract

The invention relates to compounds of formula (I), wherein R 1 , R 2 , R 1a , R 2a , R 3 , R 4 , A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.

Claims (631)

1. A compound of formula (I)

wherein

X represents a carbon atom, and R 1a and R 2a together form a bond; or

X represents a carbon atom, R 1a represents hydrogen or (C 1-4 )alkoxy, and R 2a represents hydrogen;

R 1 and R 2 , if not indicated otherwise, independently represent hydrogen; (C 1-5 )alkyl; aryl, which is unsubstituted, or independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl,

(C 1-4 )alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, and (C 3-6 )cycloalkyl; or

heteroaryl, which is unsubstituted, or independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl,

(C 1-4 )alkoxy, halogen, cyano, trifluoromethyl, and trifluoromethoxy; with the proviso that in the case R 2 represents aryl or heteroaryl, R 1 may not represent aryl or heteroaryl, wherein the aryl and heteroaryl independently are unsubstituted or substituted as defined before;

R 3 represents hydrogen, or —CO—R 31 ;

R 31 represents (C 1-5 )alkyl, (C 1-3 )fluoroalkyl, (C 3-6 )cycloalkyl, (C 3-6 )cycloalkyl-(C 1-3 )alkyl, (C 1-5 )alkoxy, (C 1-2 )alkoxy-(C 1-3 )alkyl, or R 32 R 33 N—;

R 32 represents (C 1-5 )alkyl;

R 33 represents hydrogen, or (C 1-5 )alkyl;

n represents the integer 1, 2, 3, or 4;

B represents a group —(CH 2 ) m —, wherein m represents the integer 1, 2, 3, 4, or 5; or B together with R 4 and the nitrogen atom to which B and R 4 are attached forms a 4- to 6-membered saturated ring;

A represents a linear (C 1-3 )alkan-diyl chain, wherein said linear (C 1-3 )alkan-diyl chain is optionally substituted with one or more methyl;

R 4 represents hydrogen; (C 1-5 )alkyl; (C 1-2 )alkoxy-(C 1-3 )alkyl; (C 1-3 )fluoroalkyl;

(C 3-6 )cycloalkyl; (C 3-6 )cycloalkyl-(C 1-3 )alkyl; or R 4 together with B and the nitrogen atom to which R 4 and B are attached forms a 4- to 6-membered saturated ring;

W represents aryl, which is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, and (C 3-6 )cycloalkyl;

or W represents heteroaryl, which is unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, trifluoromethyl, and trifluoromethoxy;

or W represents a group selected from:

wherein

R 5 represents hydrogen, or (C 1-5 )alkyl;

R 6 and R 7 independently represent hydrogen; (C 1-5 )alkyl; or phenyl, which is independently unsubstituted, mono-, or di-substituted, wherein each substituent is independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen and trifluoromethyl;

R 8 , R 9 and R 10 independently represent hydrogen, halogen, (C 1-5 )alkyl, hydroxy, (C 1-5 )alkoxy, —O—CO—(C 1-5 )alkyl, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, —COOH, —CO—(C 1-5 )alkoxy, (C 1-2 )alkoxy-(C 1-4 )alkoxy, or —NH—CO—(C 1-5 )alkyl;

in a free or a salt form.

2. The compound according to claim 1 , wherein the configuration of the bridged cyclohexane, or cyclohexene moiety is such that the R 3 —O— substituent and the bridge A of the cyclohexane or cyclohexene moiety are in cis relation; in a free or a salt form.

3. The compound according to claim 1 , wherein X represents a carbon atom; R 1a and R 2a together form a bond; R 1 represents aryl, which is unsubstituted, mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen and trifluoromethyl; or R 1 represents unsubstituted heteroaryl; and R 2 represents hydrogen or (C 1-5 )alkyl;

in a free or a salt form.

4. The compound according to claim 1 , wherein

A represents —(CH 2 ) p —, wherein p represents the integer 2 or 3;

in a free or a salt form.

5. The compound according to claim 1 , wherein R 3 represents —CO—R 31 ; and R 31 represents (C 1-5 )alkyl, (C 1-3 )fluoroalkyl, or (C 3-6 )cycloalkyl;

in a free or a salt form.

6. The compound according to claim 1 , wherein

B represents a group —(CH 2 ) m —, and m represents the integer 1 to 3;

in a free or a salt form.

7. The compound according to claim 1 , wherein

n represents the integer 2;

in a free or a salt form.

8. The compound according to claim 1 , wherein

R 4 represents (C1-5)alkyl;

in a free or a salt form.

9. The compound according to claim 1 , wherein

W represents

in a free or a salt form.

10. The compound according to claim 9 , wherein W represents

wherein R 8 and R 10 are independently (C 1-5 )alkoxy, and R 5 and R 9 represent hydrogen;

in a free or a salt form.

11. The compound according to claim 1 , selected from the group consisting of

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-p-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-p-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-pyridin-3-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-pyridin-3-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-naphthalen-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-naphthalen-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[2-(1H-Benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[2-(1H-Benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[(1H-Benzoimidazol-2-ylmethyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[(1H-Benzoimidazol-2-ylmethyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[Methyl-(3-phenyl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[Methyl-(3-phenyl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]methyl-amino}-ethyl)-6-methyl-5-propyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-methyl-5-propyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

2-(3-{[2-((1S,2S,4S)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester;

2-(3-{[2-((1R,2R,4R)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester;

2-(3-{[2-((1S,2S,4S)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

2-(3-{[2-((1R,2R,4R)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiophen-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiophen-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiazol-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiazol-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-oxazol-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-oxazol-2-yl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(4-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(5,6-Dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(5,6-Dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(5,6-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(5,6-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(5-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(5-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(7-Methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(7-Methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(7-Ethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(7-Ethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[2-(4-Methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[2-(4-Methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(7-Isopropoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(7-Isopropoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

2-(3-{[2-((1S,2S,4S)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-3H-benzoimidazol-4-ol;

2-(3-{[2-((1R,2R,4R)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-3H-benzoimidazol-4-ol;

(1S,5S,6S)-6-(2-{[3-(7-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1R,5R,6R)-6-(2-{[3-(7-Methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1S,2S,4S)-2-(2-{[3-(4-Methoxy-1-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4-Methoxy-1-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[2-(3,4-Diethoxy-phenyl)-ethyl]-ethyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[2-(3,4-Diethoxy-phenyl)-ethyl]-ethyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(3,4-Dimethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(3,4-Dimethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(3,4-Diethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(3,4-Diethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[(3-Furo[2,3-b]pyridin-5-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[(3-Furo[2,3-b]pyridin-5-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{Methyl-[3-(2-methyl-furo[2,3-b]pyridin-5-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{Methyl-[3-(2-methyl-furo[2,3-b]pyridin-5-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[Methyl-(3-pyridin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[Methyl-(3-pyridin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[(3-Isoquinolin-4-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[(3-Isoquinolin-4-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[Methyl-(3-quinolin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[Methyl-(3-quinolin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-{2-[Methyl-(3-quinolin-4-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-{2-[Methyl-(3-quinolin-4-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2R,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

N-[2-(3-{[2-((1S,2S,4S)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazol-4-yl]-acetamide;

N-[2-(3-{[2-((1R,2R,4R)-2-Hydroxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazol-4-yl]-acetamide;

(1S,2S,4S)-2-(2-{[3-(4-Chloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4-Chloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(7-Chloro-4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(7-Chloro-4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(4,6-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4,6-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(4,7-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4,7-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4,6-Bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-[2-({3-[4-(2-Methoxy-ethoxy)-1H-benzoimidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-[2-({3-[4-(2-Methoxy-ethoxy)-1H-benzoimidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(4,5-Dimethoxy-7-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(4,5-Dimethoxy-7-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,5S,6S)-6-(2-{[3-(7-Methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1R,5R,6R)-6-(2-{[3-(7-Methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1S,2S,4S)-2-(2-{Methyl-[3-(4-trifluoromethoxy-1H-benzoimidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{Methyl-[3-(4-trifluoromethoxy-1H-benzoimidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,5S,6S)-6-(2-{[3-(4,7-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1R,5R,6R)-6-(2-{[3-(4,7-Dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R,5R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

(1S,2S,4S,5S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

(1S,2S,4R,5S)-2-(2-{[341H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

(1R,2R,4S,5R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

(1R,2R,4R,5S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

(1S,2S,4S,5R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]octan-2-ol;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-p-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]methyl-amino}-ethyl)-5-p-tolyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-fluoro-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-pyridin-3-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-pyridin-3-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-naphthalen-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-naphthalen-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[2-(1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[2-(1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[(1H-benzoimidazol-2-ylmethyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[(1H-benzoimidazol-2-ylmethyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[methyl-(3-phenyl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[methyl-(3-phenyl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-methyl-5-propyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-6-methyl-5-propyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2R,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2S,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methyl-6-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

2-(3-{[2-((1S,2S,4S)-2-Isobutyryloxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester;

2-(3-{[2-((1R,2R,4R)-2-Isobutyryloxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-4-carboxylic acid methyl ester;

2-(3-{[2-((1S,2S,4S)-2-Isobutyryloxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

2-(3-{[2-((1R,2R,4R)-2-Isobutyryloxy-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl)-ethyl]-methyl-amino}-propyl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiophen-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiophen-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(4-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiazol-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-thiazol-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-oxazol-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[341H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-oxazol-2-yl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Cyclobutanecarboxylic acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Cyclobutanecarboxylic acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

3,3,3-Trifluoro-propionic acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

3,3,3-Trifluoro-propionic acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Cyclopropanecarboxylic acid (1S,2S,4S)-2-(2-{[3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Cyclopropanecarboxylic acid (1R,2R,4R)-2-(2-{[3-(5,6-dichloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(5-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(5-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-ethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-ethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[2-(7-methoxy-1H-benzoimidazol-2-yl)-ethyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-isopropoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-isopropoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-isobutyryloxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-isobutyryloxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-hydroxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-hydroxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,5S,6S)-6-(2-{[3-(7-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1R,5R,6R)-6-(2-{[3-(7-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

3,3,3-Trifluoro-propionic acid (1S,5S,6S)-6-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

3,3,3-Trifluoro-propionic acid (1R,5R,6R)-6-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[2-(3,4-diethoxy-phenyl)-ethyl]-ethyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[2-(3,4-diethoxy-phenyl)-ethyl]ethyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(3,4-dimethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(3,4-dimethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(3,4-diethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(3,4-diethoxy-phenyl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[(3-furo[2,3-b]pyridin-5-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[(3-furo[2,3-b]pyridin-5-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{methyl-[3-(2-methyl-furo[2,3-b]pyridin-5-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{methyl-[3-(2-methyl-furo[2,3-b]pyridin-5-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[methyl-(3-pyridin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[methyl-(3-pyridin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,5-diphenyl-1H-imidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,5-diphenyl-1H-imidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[(3-isoquinolin-4-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[(3-isoquinolin-4-yl-propyl)-methyl-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[methyl-(3-quinolin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[methyl-(3-quinolin-3-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-{2-[methyl-(3-quinolin-4-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-{2-[methyl-(3-quinolin-4-yl-propyl)-amino]-ethyl}-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

2,2-Dimethyl-propionic acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

2,2-Dimethyl-propionic acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isopropyl-carbamic acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isopropyl-carbamic acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

2-Methoxy-2-methyl-propionic acid (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

2-Methoxy-2-methyl-propionic acid (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Carbonic acid isopropyl ester (1S,2S,4S)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Carbonic acid isopropyl ester (1R,2R,4R)-2-(2-{[3-(4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4-acetylamino-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4-acetylamino-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4-chloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4-chloro-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(7-chloro-4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(7-chloro-4-methoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,6-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,6-bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,6-bis-trifluoromethyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-[2-({3-[4-(2-methoxy-ethoxy)-1H-benzoimidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-[2-({3-[4-(2-methoxy-ethoxy)-1H-benzoimidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,5-dimethoxy-7-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,5-dimethoxy-7-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,5S,6S)-6-(2-{[3-(7-methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1R,5R,6R)-6-(2-{[3-(7-methoxy-4-methyl-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{methyl-[3-(4-trifluoromethoxy-1H-benzoimidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{methyl-[3-(4-trifluoromethoxy-1H-benzoimidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,5S,6S)-6-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1R,5R,6R)-6-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{methyl-[3-(4-methyl-5-phenyl-1H-imidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{methyl-[3-(4-methyl-5-phenyl-1H-imidazol-2-yl)-propyl]-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-[2-({3-[5-(2-methoxy-phenyl)-1H-imidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-[2-({3-[5-(2-methoxy-phenyl)-1H-imidazol-2-yl]-propyl}-methyl-amino)-ethyl]-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R,5R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1S,2S,4S,5R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1R,2R,4R,5S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1S,2S,4S,5S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,2R,4R,5R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1S,2S,4S,5S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

Isobutyric acid (1R,2S,4R,5S)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]oct-2-yl ester; and

Isobutyric acid (1S,2R,4S,5R)-2-(2-{[3-(1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-methoxy-5-phenyl-bicyclo[2.2.2]oct-2-yl ester;

in a free or a salt form.

12. The compound according to claim 1 , wherein

X represents a carbon atom; R 1a and R 2a together form a bond; R 1 represents unsubstituted aryl;

R 2 represents hydrogen; and

A represents —(CH 2 ) p —, wherein p represents the integer 2 or 3;

wherein the configuration of the bridged cyclohexene moiety is such that the R 3 —O— substituent and the bridge A of the cyclohexene moiety are in cis relation;

R 3 represents —CO—R 31 ; and R 31 represents (C 1-5 )alkyl;

B represents a group —(CH 2 ) m —, and m represents the integer 3;

n represents the integer 2;

R 4 represents (C 1-5 )alkyl; and

W represents

wherein

R 5 represents hydrogen; and

R 8 , R 9 and R 10 independently represent hydrogen, halogen, (C 1-5 )alkyl, (C 1-5 )alkoxy, (C 1-3 )fluoroalkyl, or (C 1-3 )fluoroalkoxy,

in a free or a salt form.

13. The compound according to claim 12 , wherein

W represents

wherein R 8 and R 10 are independently (C 1-5 )alkoxy, and R 5 and R 9 represent hydrogen;

in a free or a salt form.

14. The compound according to claim 1 , wherein the compound is selected from the group consisting of:

Isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

Isobutyric acid (1R,5R,6R)-6-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester; and

Isobutyric acid (1S,5S,6S)-6-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-8-phenyl-bicyclo[3.2.2]non-8-en-6-yl ester;

in a free or a salt form.

15. The compound according to claim 1 , wherein the compound is isobutyric acid

(1R,2R,4R)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

in a free or a salt form.

16. The compound according to claim 1 , wherein the compound is isobutyric acid

(1S,2S,4S)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;

in a free or a salt form.

17. A pharmaceutical composition comprising the compound according to claim 1 in a free or pharmaceutically acceptable salt form, and at least one therapeutically inert excipient.

18. The pharmaceutical composition according to claim 17 , wherein the compound is a compound of formula (I)

Wherein

X represents a carbon atom; R 1a and R 2a together form a bond; R 1 represents unsubstituted aryl; R 2 represents hydrogen; and

A represents —(CH 2 ) p —, wherein p represents the integer 2 or 3;

wherein the configuration of the bridged cyclohexene moiety is such that the R 3 —O— substituent and the bridge A of the cyclohexene moiety are in cis relation;

R 3 represents —CO—R 31 ; and R 31 represents (C 1-5 )alkyl;

B represents a group —(CH 2 ) m —, and m represents the integer 3;

n represents the integer 2;

R 4 represents (C 1-5 )alkyl; and

W represents

wherein R 9 and R 19 are independently (C 1-5 )alkoxy, and R 5 and R 9 represent hydrogen;

in a free or pharmaceutically acceptable salt form.

19. The pharmaceutical composition according to claim 17 , wherein the compound is isobutyric acid (1R,2R,4R)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester in a free or pharmaceutically acceptable salt form.

20. The pharmaceutical composition according to claim 17 , wherein the compound is isobutyric acid (1S,2S,4S)-2-(2-{[3-(4,7-dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester in a free or pharmaceutically acceptable salt form.

21. A method for the treatment of a disease or disorder selected from the group consisting of chronic stable angina and hypertension

comprising administering to a subject a pharmaceutically active amount of a compound according to claim 1 , in a free or pharmaceutically acceptable salt form.

22. The method according to claim 21 , wherein the disease or disorder is hypertension.

23. The method according to claim 21 , wherein said compound is selected from the group consisting of:

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(3-methoxy-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-(2,6-dimethyl-phenyl)-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-m-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1S,2S,4S)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-o-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;

(1R,2R,4R)-2-(2-{[3-(1H-Benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-O-tolyl-bicyclo[2.2.2]oct-5-en-2-ol;