IP Library › Granted Patent US 8,329,467
Granted Patent B2
US 8,329,467 · App. 12/598,437 · Granted Dec 11, 2012

Compositions and methods for altering pancreas or liver function

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Quick Facts
Patent No.
US 8,329,467
App. No.
12/598,437
Granted
Dec 11, 2012
Kind
B2
Abstract

Methods for altering pancreatic and liver cell function are provided, wherein the compositions and methods are based on use of netrin-4 or on altering the activity of netrin-4.

Claims (2)

1. A method for promoting differentiation of a partially differentiated pancreatic progenitor cell comprising contacting a partially differentiated pancreatic progenitor cell with an effective amount of netrin-4, thereby promoting differentiation of said pancreatic progenitor cell into a pancreatic cell which expresses Ptf1a p48 and Ngn-3.

2. A method for promoting differentiation of a partially differentiated liver progenitor cell comprising contacting a partially differentiated liver progenitor cell with an effective amount of netrin-4, thereby promoting differentiation of said liver progenitor cell into a liver cell which expresses albumin and alpha-fetoprotein.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2020
From: THE FOX CHASE CANCER CENTER FOUNDATION
To: THE INSTITUTE FOR CANCER RESEARCH
Reel/Frame 053562/0938 →
CONFIRMATORY LICENSE Recorded Jun 21, 2010
From: FOX CHASE CANCER CENTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024564/0544 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 2, 2009
From: ZARET, KENNETH S.; KASHIMA, YASUSHIGE
To: FOX CHASE CANCER CENTER
Reel/Frame 023454/0306 →