Treatment of duchenne muscular dystrophy

1. A process for the preparation of a compound of formula (I)

comprising a cyclisation of a compound of formula (II)

in the presence of an acid catalyst.

2. The process according to claim 1 , wherein the acid catalyst is methanesulfonic acid or p-toluenesulfonic acid.

3. The process according to claim 1 , wherein the process takes place in a solvent which is heated under reflux.

4. The process according to claim 3 , wherein the solvent is a mixture of xylenes.

5. The process according to claim 1 wherein water produced as a by-product of the cyclisation is removed.

6. The process according to claim 5 wherein the water is removed by use of Dean-Stark apparatus.

7. The process according to claim 1 , wherein the compound of formula (II) is synthesised in a solvent and subsequently cyclised without intermediate purification of the compound of formula (II) or removal of the solvent.

8. The process according to claim 1 , wherein the compound of formula (II) is prepared by the reaction of an aminoalcohol of formula (III)

with an acyl derivative of formula (IV) wherein X represents a leaving group

9. The process according to claim 8 , wherein X represents halogen.

10. The process according to claim 8 , wherein X represents Cl.