Composition of ashwagandha and indian gooseberry
View Patent ↗A therapeutic composition comprising extracts of the plant species ashwagandha ( Withania somnifera ) and Indian gooseberry ( Phyllanthus emblica ). A composition of ashwagandha and Indian gooseberry may: (1) lower cortisol and increase DHEA, (2) prevents free radical-induced photoaging, (3) inhibit collagenase activity in vitro, (4) inhibit hyaluronidase activity in vitro, (5) display superior cascading antioxidant activity, (6) reduce C-reactive protein, (7) enhance mood.
1. A therapeutic composition for internal use by a human subject in the reduction of premature skin aging consisting essentially of a skin age reducing synergistically effective combination of an extract of Phyllanthus emblica and an extract of Withania somnifera wherein said Phyllanthus emblica and said Withania somnifera are present in the composition in a weight ratio of about 1:7 Phyllanthus emblica to Withania somnifera to a weight ratio of about 7:1 Phyllanthus emblica to Withania somnifera.
2. The therapeutic composition according to claim 1 , wherein said Phyllanthus emblica and said Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 2:6 Phyllanthus emblica to Withania somnifera.
3. The therapeutic composition according to claim 1 , wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 3:5 Phyllanthus emblica to Withania somnifera.
4. The therapeutic composition according to claim 1 , wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 2:2 Phyllanthus emblica to Withania somnifera.
5. The therapeutic composition according to claim 1 , wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 5:3.
6. The therapeutic composition according to claim 1 , comprising about 60 wt. % Withania somnifera to about 65 wt. % Withania somnifera and about 35 wt. % Phyllanthus emblica to about 40 wt. % Phyllanthus emblica.
7. The therapeutic composition according to claim 1 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to synergistically inhibit collagenase.
8. The therapeutic composition according to claim 7 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide at least a 50% activity inhibition of collagenases Type I and Type IV.
9. The therapeutic composition according to claim 1 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to synergistically inhibit hyaluronidase.
10. The therapeutic composition according to claim 9 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide at least 86% inhibition of hyaluronidase activity at 1:1000.
11. The therapeutic composition according to claim 1 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide an ORAC (Oxygen Radical Absorbance Capacity) value of at least 967 μmole Trolox equivalents/g.
12. The therapeutic composition according to claim 1 , wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide an HORAC (Hydroxyl Radical Antioxidant Capacity) value of 154 μmole caffeic acid equivalents/g.