IP Library › Granted Patent US 8,722,075
Granted Patent B2
US 8,722,075 · App. 12/605,746 · Granted May 13, 2014

Compositions and methods for promoting bone formation

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Quick Facts
Patent No.
US 8,722,075
App. No.
12/605,746
Granted
May 13, 2014
Kind
B2
Abstract

A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.

Claims (11)

1. A load-bearing implant for promoting bone formation comprising:

an implantable material comprising a demineralized bone matrix, fully mineralized bone, calcium and mesenchymal stem cells, wherein the mesenchymal stems cells are seeded within the implant; and

a stimulating substance, wherein the stimulating substance stimulates osteoclast formation and the stimulating substance comprises osteoclast precursor cells that stimulate osteoclast formation, and the implant includes the mesenchymal stem cells and the osteoclast precursor cells in a ratio of 1:4.

2. The implant of claim 1 , wherein the material further comprises hydroxyapatite.

3. The implant of claim 1 , wherein the material further comprises a calcium phosphate material.

4. The implant of claim 1 , further comprising a second stimulating substance, wherein the second stimulating substance stimulates osteoblast formation or recruitment in vivo.

5. The implant of claim 1 , further comprising a second stimulating substance, wherein the second stimulating substance enhances resorbing activity of osteoclasts in vivo.

6. The implant of claim 1 , wherein the stimulating substance further comprises one of RANKL, MCSF, ADAM-12, PTH, PTHrP, VEGF, hydrocortisone, 1,25 dihydroxyvitamin D3, PGE2, TNFalpha, IL-1beta, IL-3, IL-6, IL-11, and bFGF.

7. The implant of claim 1 , wherein the stimulating substance further comprises a DNA that encodes one or more of RANKL, MCSF, ADAM-12, PTH, PTHrP, VEGF, TNFalpha, IL-1beta, IL-3, IL-6, IL-11, and bFGF.

8. The implant of claim 1 , wherein the implantable material comprises large segmental allograft pieces.

9. The implant of claim 1 , wherein the mesenchymal stems cells comprise mesenchymal cell line C2C12.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 28, 2011
From: OSTEOTECH, INC.
To: WARSAW ORTHOPEDIC, INC.
Reel/Frame 026196/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 20, 2010
From: BEHNAM, KEYVAN
To: OSTEOTECH, INC.
Reel/Frame 025527/0759 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 16, 2010
From: SHIMP, LAWRENCE A.; WEI, GUOBAO; SELIM, ABDULHAFEZ A.
To: OSTEOTECH, INC.
Reel/Frame 024087/0575 →