Method of preventing and treating airway remodeling and pulmonary inflammation using A
View Patent ↗The present invention relates to methods of preventing airway remodeling using A 2B adenosine receptor antagonists. This invention finds utility in the treatment and prevention of asthma, COPD, pulmonary fibrosis, emphysema, and other pulmonary diseases. The invention also relates to pharmaceutical compositions for use in the method.
1. A method for the treatment of chronic obstructive pulmonary disease (COPD), said method comprising administering to a mammal in need thereof a pharmaceutical composition comprising a therapeutically effective amount of 3-ethyl-1-propyl-8- {1- [(3-trifluoromethylphenyl)methyl]pyrazol-4-yl}-1,3,7-trihydropurine-2,6-dione, having the chemical structure
wherein an A 3 adenosine receptor antagonist is not administered to said mammal.
2. The method of claim 1 , wherein the administration is oral.
3. The method of claim 1 , wherein the administration is intravenous.
4. The method of claim 1 , wherein the administration is intramuscular.
5. The method of claim 1 , wherein the administration is intraperitoneal.
6. The method of claim 1 , wherein the administration is by inhalation.