Reinforced biologic material
View Patent ↗The present disclosure provides an implantable medical device comprising a composite graft material including a first biologic component, such as an acellular tissue matrix, and a second non-biologic component.
1. An implantable medical device comprising:
a plurality of first elongate non-biologic elements, at least a portion of which are under a tensile or compressive stress prior to implantation;
at least one biologic component surrounding at least a portion of the plurality of first elongate elements;
at least one second elongate non-biologic element, wherein the at least one second element secures at least one end portion of the plurality of first elongate non-biologic elements; and
further comprising at least one non-biologic, bioabsorbable sheath, wherein the non-biologic, bioabsorbable sheath at least partially covers the plurality of first elongate non-biologic elements.
2. The implantable medical device of claim 1 , wherein the non-biologic, bioabsorbable sheath comprises a textile material, wherein the textile material comprises a non-biologic material and has a knit, weave, braid, or nonwoven structure, or a combination thereof.
3. The implantable medical device of claim 1 , wherein the at least one biologic component forms a sheath about the plurality of first elongate non-biologic elements.
4. The implantable medical device of claim 1 , wherein the at least one second elongate element secures at least one end of the plurality of first elongate non-biologic elements by at least one of whipping, wrapping, and winding.
5. The implantable medical device of claim 4 , wherein the at least one second elongate element forms a screw-thread pattern compatible with the threads of an anchoring screw.
6. The implantable medical device of claim 1 , wherein the at least one second elongate portion comprises the same material as the plurality of first elongate non-biologic elements.
7. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises at least one material chosen from bioabsorbable polymer, bioabsorbable metal, or a combination of bioabsorbable polymer and bioabsorbable metal.
8. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprise at least one material chosen from polyhydroxyalkanoate, poly-hydroxybutyrate, polylactic acid (PLA), polyglycolic acid (PGA), polylactideglycolide acid (PLGA), polydioxanone (PDO), polycaprolactone (PCL), a polyanhydride, a polyorthoester, a poly(amino acid), a polypeptide, a polydepsipeptide, a nylon-2/nylon-6 copolyamide, a poly(alkylene succinate), poly(hydroxyl butyrate) (PHB), poly (butylene diglocolate), poly (C-caprolactone), a polydihydropyran, a polyphosphazene, a poly (cyano acrylates), modified polysaccharides, cellulose, starch, chitin, modified proteins, collagen, fibrin, and combinations and copolymers thereof.
9. The implantable medical device of claim 1 , wherein the at least one biologic component comprises a biomatrix.
10. The implantable medical device of claim 9 , wherein the biomatrix comprises an acellular tissue matrix or a particulate acellular tissue matrix.
11. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements has a higher load capacity than the at least one biologic component at the time of implantation.
12. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements are under a tensile stress ranging from greater than 0N to about 1800N.
13. The implantable medical device of claim 1 , wherein the plurality of first elongate non-biologic elements comprises a plurality of threads, cords, cables, ribbons, or braids.