TGR5 modulators and methods of use thereof
View Patent ↗The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
1. A compound Ih3e of the chemical structure:
or a pharmaceutically acceptable salt, or glycine or taurine amino acid conjugate thereof.
2. The compound according to claim 1 , wherein the compound is a pharmaceutically acceptable salt.
3. A pharmaceutically acceptable composition comprising a compound according to claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
4. A method of treating diabetes or obesity in a subject in need of said treatment comprising administering a compound Ih3e of the chemical structure:
or a pharmaceutically acceptable salt thereof.
5. A kit for treating diabetes or obesity in a subject in need of said treatment, wherein the kit comprises a compound Ih3e of the chemical structure:
or a pharmaceutically acceptable salt thereof.
6. The compound according to claim 1 , wherein the compound is a glycine amino acid conjugate.
7. The compound according to claim 1 , wherein the compound is a taurine amino acid conjugate.
8. The method of claim 4 of treating diabetes.
9. The method of claim 4 of treating obesity.