IP Library Granted Patent US 8,574,146
Granted Patent B2
US 8,574,146 · App. 12/625,508 · Granted Nov 5, 2013

Implant with high vapor pressure medium

Inventors: John Gillespie, Jr. (Dover, MA); Kevin G. Connors (Wellesley, MA); Ernest G. Schutt (San Diego, CA); Peter Dayton (Charlestown, MA)
Assignee: AttenueX Technologies, Inc.
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Quick Facts
Patent No.
US 8,574,146
App. No.
12/625,508
Granted
Nov 5, 2013
Kind
B2
Abstract

An implant for use in a human or animal body can include a flexible housing with an outer wall and having a chamber therein. The implant can have at least one high vapor pressure medium within the chamber. The at one high vapor pressure medium can have a combined vapor pressure equal to or greater than about the average value of the hydrostatic pressure of the implantation site plus the skin tension of the housing minus the gas tension of the dissolved gasses present at the implantation site.

Claims (35)

1. A device for use in a human or animal body, comprising:

a flexible housing comprising an outer wall and defining a chamber therein; and

at least one high vapor pressure medium having a vapor pressure greater than the pressure in an anatomical structure and a low permeability rate through the outer wall of less than 1 ml/day at body temperature;

wherein said high vapor pressure medium is a liquid at body temperature.

2. A device as in claim 1 , wherein said high vapor pressure media comprises at least one of heptafluoropropane, perfluorooctylbromide, perfluorohexane, perfluorodecalin, tetrafluoroethane, sulfur hexafluoride, hexafluoroethane, perfluoropropane, perfluorobutane, perfluoropentane, perfluoroheptane, perfluorooctane, octafluoropropane, decafluoro-n-butane and perfluoroperhydrophenanthrene.

3. A device as in claim 1 , wherein said high vapor pressure medium has a solubility of less than about 0.1 ml per ml of urine at body temperature and pressure.

4. A device as in claim 1 , wherein said housing is configured to be positioned within an anatomical structure while in a first, introduction configuration and then at least partially inflated into a second, implanted configuration.

5. A device as in claim 1 , wherein said device is an inflatable attenuation device.

6. A device as in claim 1 , wherein said device is an implantable pressure attenuation device.

7. A device as in claim 1 , wherein the at least one high vapor pressure medium comprises a vapor and a reservoir of liquid.

8. A device as in claim 1 , wherein the device is a device for attenuating and/or baffling transient pressure waves in relatively incompressible materials in organs in a human or animal body.

9. A device as in claim 1 , wherein the device is adapted to reversibly occupying intraorgan space.

10. A device as in claim 1 , wherein the outer wall is made of a gas permeable material that allows permeation of gas at a rate of at least 15 ml per twelve months in or out of the device.

11. A device as in claim 1 , wherein said anatomical structure is the bladder.

12. A device for use in a human or animal body, comprising:

a flexible housing comprising an outer wall and defining a chamber therein; and

at least one high vapor pressure medium having a vapor pressure greater than the pressure in an anatomical structure and a low permeability rate through the outer wall of less than 1 ml/day at body temperature;

wherein said high vapor pressure medium has a solubility of less than about 0.1 ml per ml of urine at body temperature and pressure.

13. A device as in claim 12 , wherein said high vapor pressure media comprises at least one of heptafluoropropane, perfluorooctylbromide, perfluorohexane, perfluorodecalin, tetrafluoroethane, sulfur hexafluoride, hexafluoroethane, perfluoropropane, perfluorobutane, perfluoropentane, perfluoroheptane, perfluorooctane, octafluoropropane, decafluoro-n-butane and perfluoroperhydrophenanthrene.

14. A device as in claim 12 , wherein said housing is configured to be positioned within an anatomical structure while in a first, introduction configuration and then at least partially inflated into a second, implanted configuration.

15. A device as in claim 12 , wherein said device is an inflatable attenuation device.

16. A device as in claim 12 , wherein said device is an implantable pressure attenuation device.

17. A device as in claim 12 , wherein the at least one high vapor pressure medium comprises a vapor and a reservoir of liquid.

18. A device as in claim 12 , wherein the device is a device for attenuating and/or baffling transient pressure waves in relatively incompressible materials in organs in a human or animal body.

19. A device as in claim 12 , wherein the outer wall is made of a gas permeable material that allows permeation of gas at a rate of at least 15 ml per twelve months in or out of the device.

20. A device for use in a human or animal body, comprising:

a flexible housing comprising an outer wall and defining a chamber therein, wherein the outer wall is made of a gas permeable material that allows permeation gas at a rate of at least 15 ml per twelve months in or out of the device; and

at least one high vapor pressure medium having a vapor pressure greater than the pressure in an anatomical structure and a low permeability rate through the outer wall of less than 1 ml/day at body temperature.

21. A device as in claim 20 , wherein said high vapor pressure media comprises at least one of heptafluoropropane, perfluorooctylbromide, perfluorohexane, perfluorodecalin, tetrafluoroethane, sulfur hexafluoride, hexafluoroethane, perfluoropropane, perfluorobutane, perfluoropentane, perfluoroheptane, perfluorooctane, octafluoropropane, decafluoro-n-butane and perfluoroperhydrophenanthrene.

22. A device as in claim 20 , wherein said housing is configured to be positioned within an anatomical structure while in a first, introduction configuration and then at least partially inflated into a second, implanted configuration.

23. A device as in claim 20 , wherein said device is an inflatable attenuation device.

24. A device as in claim 20 , wherein said device is an implantable pressure attenuation device.

25. A device as in claim 20 , wherein the at least one high vapor pressure medium comprises a vapor and a reservoir of liquid.

26. A device as in claim 20 , wherein the device is adapted to reversibly occupying intraorgan space.

27. A device as in claim 20 , wherein said anatomical structure is the bladder.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2019
From: ATTENUEX TECHNOLOGIES, INC.
To: SOLACE THERAPEUTICS, INC.
Reel/Frame 049282/0097 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 17, 2010
From: GILLESPIE, JR., JOHN; CONNORS, KEVIN G.; SCHUTT, ERNEST G.; DAYTON, PETER
To: ATTENUEX TECHNOLOGIES, INC.
Reel/Frame 024399/0076 →
Continuity (9)
Continuation In Part 12343120 · Dec 23, 2008
Division 10391448 · Mar 17, 2003
Continuation 10391446 · Mar 17, 2003
Continuation In Part 09723309 · Nov 27, 2000
Provisional Application 60415949 · Oct 3, 2002
Provisional Application 60197095 · Apr 14, 2000
Provisional Application 61200147 · Nov 25, 2008
Provisional Application 61211515 · Mar 31, 2009
Related Publication 20100222802A1 · Sep 2, 2010