Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers
View Patent ↗The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein L 1 , L 2 , R 1 , R 2 , and R 3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
1. A compound of formula (I),
or a pharmaceutically acceptable salt thereof, wherein
L 1 is C(O), S(O) 2 , SO 2 N(R 4 ), C(O)O or —(CR a R b ) m —;
R 1 is alkyl, G 1 , —CH(G 1 ) 2 , —(CR a R b ) m -G 1 , —(CR a R b ) m —CH(G 1 ) 2 , —(CR e R f ) n —N(R 5 ) 2 , —(CR e R f ) n —N(R 5 )—C(O)O(alkyl), —(CR e R f ) n —N(R 5 )—C(O)(alkyl), or —(CR e R f ) n —N(R 5 )—SO 2 R 6 ; or
L 1 -R 1 taken together are hydrogen, alkyl, hydroxyalkyl, G 1 , or —CH(G 1 ) 2 ;
L 2 is —(CR c R d ) p —, C(O), C(O)N(R 4 ), S(O) 2 , SO 2 N(R 5 ), or C(O)O;
R 2 is alkyl, G 2 , —C(R c )(G 2 )(G 3 ), —(CR c R d ) p —CH(G 2 )(G 3 ), —(CR g R h ) q —N(R 5 )—C(O)O(alkyl), —(CR g R h ) q —N(R 5 )—C(O)O-G 2 , —(CR g R h ) q —N(R 5 )—C(O)(alkyl), —(CR g R h ) q —N(R 5 )—SO 2 R 6 , —(CR g R h ) q —N(R 4 )(R 5 ), —(CR g R h ) q —N(R 5 )—C(O)N(R 5 )-(alkyl), or (CR g R h ) q —N(R 5 )—C(O)N(R 5 )-G 2 , —(CR c R d ) p -aryl, —(CR c R d ) p -cycloalkyl, —(CR c R d ) p -cycloalkenyl, —(CR c R d ) p -heteroaryl, or —(CR c R d ) p -heterocycle; wherein the aryl, cycloalkyl, cycloalkenyl, and heteroaryl groups of —(CR c R d ) p -aryl, —(CR c R d ) p -cycloalkyl, —(CR c R d ) p -cycloalkenyl, and —(CR c R d ) p -heteroaryl are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, oxo, phenyl, N(R 7 ) 2 , N(R 7 )C(O)R 7 , OR 7 , C(O)R 7 , C(O)OR 7 , C(O)N(R 7 ) 2 , SO 2 R 8 , and SO 2 N(R 7 ) 2 ; wherein the heterocycle group of —(CR c R d ) p -heterocycle is unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, oxo, N(R 7 ) 2 , N(R 7 )C(O)R 7 , OR 7 , C(O)R 7 , C(O)OR 7 , C(O)N(R 7 ) 2 , SO 2 R 8 , and SO 2 N(R 7 ) 2 ; or
L 2 -R 2 taken together are aryl, cycloalkyl, cycloalkenyl, monocyclic heteroaryl, heterocycle, or —C(R c )(G 2 )(G 3 ); wherein the aryl, cycloalkyl, cycloalkenyl, monocyclic heteroaryl and heterocycle groups of aryl, cycloalkyl, cycloalkenyl, monocyclic heteroaryl, and heterocycle are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, oxo, phenyl, N(R 7 ) 2 , N(R 7 )C(O)R 7 , OR 7 , C(O)R 7 , C(O)OR 7 , C(O)N(R 7 ) 2 , SO 2 R 8 , and SO 2 N(R 7 ) 2 ;
m and p, at each occurrence, are each independently 1, 2, 3, 4, 5, or 6;
n and q, at each occurrence, are each independently 1, 2, 3, 4, or 5;
R a , R b , R c , and R d , at each occurrence, are each independently hydrogen, alkyl, arylalkyl, halogen, haloalkyl or OR 7 ; or
R a and R b , or R c and R d , together with the carbon atom to which they are attached, optionally form a C 3-6 cycloalkyl ring;
R e , R f , R g , and R h , at each occurrence, are each independently hydrogen, alkyl, halogen, haloalkyl, OR 7 , cycloalkylalkyl, heteroaryl, arylalkyl, or heteroarylalkyl; wherein the aryl, cycloalkyl and heteroaryl groups of aryl, cycloalkyl and heteroaryl are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of alkyl and haloalkyl;
G 1 , G 2 , and G 3 at each occurrence, are each independently aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; wherein G 1 , G 2 , and G 3 at each occurrence are each independently unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, cyano, haloalkyl, halogen, nitro, oxo, phenyl, N(R 7 ) 2 , N(R 7 )C(O)R 7 , OR 7 , C(O)R 7 , C(O)OR 7 , C(O)N(R 7 ) 2 , SO 2 R 8 , and SO 2 N(R 7 ) 2 ; and wherein G 1 is other than quinoline, quinazolinedione, or pyridopyrimidinedione;
R 3 is hydrogen, alkyl, haloalkyl, cycloalkyl, or cycloalkylalkyl;
R 4 , R 5 , and R 7 , at each occurrence, are each independently hydrogen, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, or haloalkyl; wherein said aryl, the aryl of arylalkyl and cycloalkyl are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen;
R 6 is alkyl, aryl, cycloalkyl, cycloalkenyl, heteroaryl, or heterocycle; wherein said aryl, heteroaryl, and heterocycle are independently unsubstituted or substituted with 1, 2 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, and halogen;
R 8 is alkyl or haloalkyl;
with the proviso that L 1 -R 1 and L 2 -R 2 are not both alkyl at the same time;
and with the proviso that when L 1 -R 1 is alkyl, L 2 -R 2 is other than C(O)N(R 4 ), wherein R 4 is alkyl;
and with the further proviso that the compound is other than:
N-(2-trityloctahydrocyclopenta[c]pyrrol-4-yl)acetamide;
N-(octahydrocyclopenta[c]pyrrol-4-yl)acetamide-N-methyl-N-(2-trityloctahydrocyclopenta[c]pyrrol-4-yl)acetamide;
N-methyl-N-(octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
6-(2-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl)octahydrocyclopenta[c]pyrrol-4-ylamino)methyl-2H-pyrido[3,2-b][1,4]thiazin-3(4H)-one;
tert-butyl 2-(2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)ethyl)octahydrocyclopenta[c]pyrrol-4-ylcarbamate;
tert-butyl 2-benzyl octahydrocyclopenta[c]pyrrol-4-ylcarbamate; or
tert-butyl octahydrocyclopenta[c]pyrrol-4-ylcarbamate.
2. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —;
R a and R b are each hydrogen;
m is 1;
R 1 is G 1 ; wherein G 1 is aryl;
L 2 is C(O);
R 2 is —(CR c R d ) p -aryl;
p is 1;
R c and R d , together with the carbon atom to which they are attached form a C 3-6 cycloalkyl ring; and
R 3 is hydrogen.
3. The compound according to claim 1 , wherein
L 1 -R 1 together are alkyl; or
L 1 is —(CR a R b ) m — or C(O);
R 1 is G 1 ; wherein G 1 is aryl, cycloalkyl, or heteroaryl;
L 2 is C(O);
R 2 is —(CR c R d ) p -aryl and p is 1 or 2;
R a , R b , R c , and R d , at each occurrence are independently hydrogen, alkyl, or arylalkyl; and
R 3 is hydrogen or alkyl.
4. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —;
R a and R b at each occurrence are each hydrogen;
m is 1 or 2;
R 1 is G 1 ; wherein G 1 is aryl;
L 2 is C(O)N(R 4 ), wherein R 4 is alkyl;
R 2 is G 2 , wherein G 2 is aryl; and
R 3 is hydrogen.
5. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —, C(O) or S(O) 2 ;
R a and R b at each occurrence are each hydrogen;
m is 1;
R 1 is alkyl or G 1 ; wherein G 1 is aryl or cycloalkyl;
L 2 is C(O);
R 2 is —(CR c R d ) p -cycloalkyl or —(CR c R d ) p -heterocycle; wherein
R c and R d at each occurrence are independently hydrogen, alkyl or OR 7 ;
p is 1;
cycloalkyl and heterocycle of —(CR c R d ) p -cycloalkyl or —(CR c R d ) p -heterocycle are unsubstituted or substituted with 1, 2, 3, 4, or 5 substituents independently selected from the group consisting of alkyl, haloalkyl, halogen, oxo and C(O)OR 7 ;
R 7 is hydrogen; and
R 3 is hydrogen.
6. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —;
R a and R b at each occurrence are each hydrogen;
m is 1;
R 1 is G 1 ; wherein G 1 is aryl;
L 2 -R 2 together are cycloalkyl; and
R 3 is hydrogen or cycloalkyl.
7. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —;
R a and R b at each occurrence are each hydrogen;
m is 1;
R 1 is G 1 ; wherein G 1 is aryl;
L 2 is C(O);
R 2 is —C(R c )(G 2 )(G 3 ), or —(CR c R d ) p —CH(G 2 )(G 3 ); wherein G 2 is aryl and G 3 is aryl or cycloalkyl;
R c and R d are each hydrogen; and
R 3 is hydrogen.
8. The compound according to claim 1 , wherein
L 1 -R 1 together is hydrogen or —CH(G 1 ) 2 , wherein each G 1 is aryl or heteroaryl; or
L 1 is —(CR a R b ) m —, C(O), or S(O) 2 ;
R 1 is G 1 , —CH(G 1 )—(CR a R b ) m -G 1 , —(CR a R b ) m —CH(G 1 ) 2 , —(CR e R f ) n —N(R 5 ) 2 ; wherein each G 1 is aryl or heteroaryl;
R a and R b are each hydrogen;
R e and R f at each occurrence, are each independently hydrogen or alkyl;
R 5 at each occurrence, is independently hydrogen or alkyl;
L 2 is C(O);
R 2 is —C(R c )(G 2 )(G 3 ); wherein G 2 and G 3 are each cycloalkyl;
R e hydrogen or OR 7 , wherein R 7 is hydrogen; and
R 3 is hydrogen.
9. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m — or S(O) 2 ;
R a and R b at each occurrence are each hydrogen;
m is 1;
R 1 is G 1 ; wherein G 1 is aryl;
L 2 is C(O); and
R 2 is alkyl or G 2 , wherein G 2 is cycloalkyl or heterocycle; and
R 3 is hydrogen.
10. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —, C(O) or S(O) 2 ;
R a and R b at each occurrence are each hydrogen;
m, at each occurrence, is 1 or 2;
R 1 is G 1 , —(CR a R b ) m -G 1 , or —CH(G 1 ) 2 , wherein G 1 , at each occurrence, is independently aryl or heteroaryl;
L 2 is C(O);
R 2 is —(CR g R h ) q —N(R 5 )—C(O)O(alkyl), —(CR g R h ) q —N(R 5 )—C(O)O-G 2 , —(CR g R h ) q —N(R 5 )—C(O)(alkyl), —(CR g R h ) q —N(R 5 )—SO 2 —R 6 , —(CR g R h ) q —N(R 5 )-G 2 ; —(CR g R h ) q —N(R 5 )—C(O)N(R 5 )-(alkyl), or —(CR g R h ) q —N(R 5 )—C(O)N(R 5 )-G 2 ;
q is 1 or 2;
R g and R h , at each occurrence, are each independently hydrogen, alkyl, arylalkyl, or cycloalkylalkyl;
R 4 and R 5 at each occurrence, are each independently hydrogen, alkyl, arylalkyl, cycloalkyl or cycloalkylalkyl;
R 6 is alkyl, aryl, or cycloalkyl;
G 2 is aryl or cycloalkyl; and
R 3 is hydrogen, alkyl, cycloalkyl or cycloalkylalkyl.
11. The compound according to claim 1 , wherein
L 1 -R 1 together are hydrogen or hydroxyalkyl; or
L 1 is —(CR a R b ) m —, C(O) or S(O) 2 ;
R 1 is G 1 , —(CR a R b ) m -G 1 or —CH(G 1 ) 2 , wherein each G 1 is aryl or heteroaryl;
R a and R b , at each occurrence, are each independently hydrogen or alkyl;
L 2 is S(O) 2 ;
R 2 is G 2 , wherein G 2 is aryl or heteroaryl; and
R 3 is hydrogen, alkyl or cycloalkyl.
12. The compound according to claim 1 , wherein
L 1 is —(CR a R b ) m —;
R a and R b are each hydrogen;
R 1 is —CH(G 1 ) 2 , wherein each G 1 is aryl;
L 2 is C(O);
R 2 is —(CR c R d ) p -aryl;
p is 1;
R c and R d , at each occurrence, are each independently hydrogen or alkyl; and
R 3 is hydrogen.
13. The compound according to claim 1 , wherein
L 1 is C(O), S(O) 2 or —(CR a R b ) m —;
R a and R b , at each occurrence, are independently hydrogen or alkyl;
m is 1;
R 1 is G 1 or —(CR a R b ) m -G 1 , wherein G 1 is aryl or heteroaryl;
L 2 is —(CR c R d ) p —;
R c and R d are each hydrogen;
p is 1;
R 2 is G 2 , wherein G 2 is aryl, cycloalkyl or heteroaryl; or
L 2 -R 2 taken together are aryl, monocyclic heteroaryl, or —C(R c )(G 2 )(G 3 ), wherein G 2 and G 3 are each aryl or heteroaryl and R c is hydrogen; and
R 3 is hydrogen or alkyl.
14. The compound according to claim 1 , wherein
L 1 is C(O);
R 1 is —(CR e R f ) n —N(R 5 ) 2 ;
n is 1 or 2;
R e and R f at each occurrence are each independently hydrogen or alkyl;
R 5 at each occurrence is independently hydrogen or alkyl;
L 2 is C(O) or S(O) 2 ;
R 2 is G 2 or —C(R c )(G 2 )(G 3 ), wherein G 2 and G 3 are each aryl or heteroaryl and R c is hydrogen; and
R 3 is hydrogen, alkyl, or cycloalkyl.
15. The compound according to claim 1 , wherein
L 1 is C(O);
R 1 is —(CR e R f ) n —N(R 5 ) 2 or —(CR e R f ) n —N(R 5 )C(O)O(alkyl);
n is 1 or 2;
R e and R f at each occurrence are each independently hydrogen, alkyl, or arylalkyl;
R 5 at each occurrence is independently hydrogen, alkyl or cycloalkyl;
L 2 is C(O);
R 2 is —(CR g R h ) q —N(R 4 )(R 5 ) or —(CR g R h ) q —N(R 5 )C(O)O(alkyl);
q is 1 or 2;
R 4 is hydrogen or alkyl;
R g and R h at each occurrence are each independently hydrogen or alkyl; and
R 3 is hydrogen.
16. The compound of claim 1 , wherein
L 1 -R 1 taken together are hydrogen, G 1 or CH(G 1 ) 2 , wherein G 1 is aryl or heteroaryl;
L 2 is C(O);
R 2 is —(CR g R h ) q —N(R 4 )(R 5 ) or —(CR g R h ) q —N(R 5 )C(O)O(alkyl);
q is 1 or 2;
R 4 is hydrogen, alkyl, or cycloalkylalkyl;
R 5 is hydrogen or alkyl;
R g and R h at each occurrence are each independently hydrogen or alkyl; and
R 3 is hydrogen.
17. The compound of claim 1 , wherein
L 1 -R 1 taken together are G 1 , wherein G 1 is aryl or heteroaryl;
L 2 is C(O);
R 2 is G 2 , wherein G 2 is aryl or heteroaryl; and
R 3 is hydrogen or alkyl.
18. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclopentanecarboxamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclopentanecarboxamide;
N-[(3aR*,4R*,6aS*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclohexyl-2-phenylacetamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclohexyl-2-phenylacetamide;
N-[(3aR*,4R*,6aS*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR*,4S*,6aS*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclopentyl-2-phenylacetamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclopentyl-2-phenylacetamide;
N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclohexanecarboxamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclohexanecarboxamide;
N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
(2S)-2-(3-benzoylphenyl)-N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]propanamide;
(2S)-2-(3-benzoylphenyl)-N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]propanamide;
N-[(3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclopentyl-2-phenylacetamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylpropanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-propylpentanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]cycloheptanecarboxamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-(4-isobutylphenyl)propanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclohexanecarboxamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,3-diphenylpropanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-methyl-3-phenylpropanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-methyl-2-phenylpropanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclopropanecarboxamide;
2-benzyl-N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethylbutanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethyl-2-phenylbutanamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethyl-2-phenylbutanamide;
(2R)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethyl-2-phenylbutanamide;
(2S)—N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclopentyl-2-phenylacetamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
(2R)—N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
(2R)—N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylpropanamide;
(2S)—N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylpropanamide;
(2S)—N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-(4-isobutylphenyl)propanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclopropyl-2-phenylacetamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-cyclobutyl-2-phenylacetamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-(4-chlorophenyl)-3-methylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-ethyl-2-phenylpentanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-(4-hydroxyphenyl)-3-methylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclohexanecarboxamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-methyl-2-phenylpropanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-phenylcyclopropanecarboxamide;
2-benzyl-N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,3-diphenylpropanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-methyl-3-phenylpropanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3,3-dimethyl-2-phenylbutanamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(2-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-[4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[4-fluoro-3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
N-{(3aS,4S,6aR)-2-[3,5-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[2-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(4-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(trifluoromethoxy)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
N-{(3aS,4S,6aR)-2-[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
N-{(3aS,4S,6aR)-2-[6,6-bis(4-fluorophenyl)hexyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
N-{(3aS,4S,6aR)-2-[3-(3-chlorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(3-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(3-phenylpropyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{3-[4-(trifluoromethyl)phenyl]propyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[3-(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(pyridin-4-ylmethyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-[(3aS,4S,6aR)-2-(pyridin-3-ylmethyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-[(3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-dicyclohexyl-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-{(3aS,4R,6aR)-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
N-{(3aS,4R,6aR)-2-[3,5-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
N-{(3aS,4R,6aR)-2-[6,6-bis(4-fluorophenyl)hexyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
2,2-dicyclohexyl-N-[(3aS,4R,6aR)-2-(3,3-diphenylpropyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
N-{(3aS,4R,6aR)-2-[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
N-{(3aS,4R,6aR)-2-[4,4-bis(4-fluorophenyl)butyl]octahydrocyclopenta[c]pyrrol-4-yl}-2,2-dicyclohexylacetamide;
3-methyl-2-phenyl-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
N-[(3aR,4S,6aS)-2-(cyclohexylmethyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
3-methyl-N-[(3aR,4S,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(2-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(3-chlorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(3-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
3-methyl-2-phenyl-N-{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
N-[(3aR,4S,6aS)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(3-methoxybenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
3-methyl-N-[(3aR,4S,6aS)-2-(3-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
3-methyl-N-[(3aR,4S,6aS)-2-(2-methylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(2,6-dimethylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(2-methoxybenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(4-tert-butylbenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(4-methoxybenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-(3-cyanobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
3-methyl-2-phenyl-N-{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
3-methyl-2-phenyl-N-{(3aR,4S,6aS)-2-[2-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
N-{(3aR,4S,6aS)-2-[4-fluoro-3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[3-fluoro-4-(trifluoromethyl)-benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
3-methyl-2-phenyl-N-[(3aR,4S,6aS)-2-(thien-2-ylmethyl)octahydrocyclopenta[c]pyrrol-4-yl]butanamide;
3-methyl-2-phenyl-N-[(3aR,4S,6aS)-2-(pyridin-4-ylmethyl)octahydrocyclopenta[c]pyrrol-4-yl]butanamide;
3-methyl-2-phenyl-N-[(3aR,4S,6aS)-2-(2-phenylethyl)octahydrocyclopenta[c]pyrrol-4-yl]butanamide;
3-methyl-2-phenyl-N-[(3aR,4S,6aS)-2-(3-phenylpropyl)octahydrocyclopenta[c]pyrrol-4-yl]butanamide;
N-{(3aR,4S,6aS)-2-[3-(4-tert-butylphenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[6,6-bis(4-fluorophenyl)hexyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
3-methyl-N-{(3aR,4S,6aS)-2-[3-(2-methylphenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[3-(3-chlorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenyl-butanamide;
3-methyl-N-{(3aR,4S,6aS)-2-[3-(3-methylphenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-2-phenylbutanamide;
3-methyl-2-phenyl-N-((3aR,4S,6aS)-2-{3-[3-(trifluoromethyl)phenyl]propyl}octahydrocyclopenta[c]pyrrol-4-yl)butanamide;
N-{(3aR,4S,6aS)-2-[3-(3-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
3-methyl-2-phenyl-N-[(3aR,4S,6aS)-2-(4-phenylbutyl)octahydrocyclopenta[c]pyrrol-4-yl]butanamide;
N-{(3aR,4S,6aS)-2-[3-(3-chloro-5-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
3-methyl-2-phenyl-N-((3aR,4S,6aS)-2-{3-[4-(trifluoromethyl)phenyl]propyl}octahydrocyclopenta[c]pyrrol-4-yl)butanamide;
N-[(3aR,4S,6aS)-2-(3,3-diphenylpropyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[4,4-bis(4-fluorophenyl)butyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
N-{(3aR,4S,6aS)-2-[5,5-bis(4-fluorophenyl)pentyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-methyl-2-phenylbutanamide;
N-[(3aS,4S,6aR)-2-benzhydryloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
N-[(3aS,4R,6aR)-2-benzhydryloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-dicyclohexylacetamide;
3-methyl-2-phenyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
3,3-dimethyl-2-phenyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
2,2-dicyclohexyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2-ethyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
2-propyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}pentanamide;
N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}cyclohexanecarboxamide;
N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}cycloheptanecarboxamide;
N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}cyclopentanecarboxamide;
6,6-bis(4-fluorophenyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}hexanamide;
3,3-diphenyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}propanamide;
5,5-bis(4-fluorophenyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}pentanamide;
3,3-bis(4-fluorophenyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}propanamide;
4,4-bis(4-fluorophenyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-butanamide;
2,2-diphenyl-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-bis(4-fluorophenyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-acetamide;
N 2 -(tert-butyloxycarbonyl)-N 1 -{(3aR*,4R*,6aS*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(tert-butyloxycarbonyl)-N 1 -{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -(tert-butyloxycarbonyl)-N 2 -methyl-N 1 -{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
6,6-bis(4-fluorophenyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}hexanamide;
3,3-diphenyl-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}propanamide;
5,5-bis(4-fluorophenyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}pentanamide;
3,3-bis(4-fluorophenyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}propanamide;
4,4-bis(4-fluorophenyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
2,2-diphenyl-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-bis(4-fluorophenyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
3,3-dimethyl-2-phenyl-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
N 2 -(tert-butyloxycarbonyl)-N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(tert-butyloxycarbonyl)-N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -(tert-butyloxycarbonyl)-N 2 -methyl-N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -(tert-butyloxycarbonyl)-N 2 -methyl-L-leucinamide;
2,2-dicyclohexyl-2-hydroxy-N-{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
N 2 -(tert-butyloxycarbonyl)-N 2 -methyl-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
2,2-dicyclohexyl-2-hydroxy-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
N 2 -(tert-butyloxycarbonyl)-N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
2,2-dicyclohexyl-N-{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
N 1 -{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -{(3aR*,4R*,6aS*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -methyl-N 1 -{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -methyl-N 1 -{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -methyl-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -methyl-N 2 -(methylsulfonyl)-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-N 2 -(methylsulfonyl)-L-leucinamide;
N 2 -methyl-N 2 -(methylsulfonyl)-N 1 -{(3aS,4R,6aR) 2 -[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(methylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(methylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -(cyclopropylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}L-leucinamide;
N 2 -(isobutylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(cyclopropylsulfonyl)-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -acetyl-N 2 -methyl-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(2,2-dimethylpropanoyl)-N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(2,2-dimethylpropanoyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}L-leucinamide;
isobutyl (S)-4-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
cyclopentyl (S)-4-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
N 2 -[(tert-butylamino)carbonyl]-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -[(cyclopentylamino)carbonyl]-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -(3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
3-(trifluoromethyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzene sulfonamide;
3-(trifluoromethyl)-N-{(3aS*,4R*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzene sulfonamide;
3-(trifluoromethyl)-N-{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzene sulfonamide;
3-(trifluoromethyl)-N-{(3aR,4R,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzene sulfonamide;
3-(trifluoromethyl)-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzene sulfonamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS,4R,6aR)-2-[6,6-bis(4-fluorophenyl)hexyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS,4R,6aR)-2-[3,5-bis(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS,4R,6aR) 2 -[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS,4R,6aR)-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-3-(trifluoromethyl)benzenesulfonamide;
N-[(3aS,4S,6aR)-2-(4-hydroxybutyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
(3aS*,4S*,6aR*)-N,N-dicyclopropyl-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-amine;
(3aS*,4R*,6aR*)-2-benzyl-N-cyclopropyloctahydrocyclopenta[c]pyrrol-4-amine;
(3aS*,4S*,6aR*)-2-benzyl-N-cyclopropyloctahydrocyclopenta[c]pyrrol-4-amine;
N-[(3aS*,4S*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide;
N-cyclopropyl-N-[(3aS*,4S*,6aR*)-octahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS*,4S*,6aR*)-2-[6,6-bis(4-fluorophenyl)hexyl]octahydrocyclopenta[c]pyrrol-4-yl}-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide;
N-{(3aS*,4S*,6aR*)-2-[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-N-cyclopropyl-3-(trifluoromethyl)benzenesulfonamide;
N-cyclopropyl-3-(trifluoromethyl)-N-{(3aS*,4S*,6aR*)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}benzenesulfonamide;
2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
2,2-dicyclohexyl-N-{(3aS,4S,6aR)-2-[(2-phenylethyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{[2-(1-naphthyl)ethyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{[3-(trifluoromethyl)benzyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
2,2-dicyclohexyl-N-((3aS,4S,6aR)-2-{[2-(4-fluorophenyl)ethyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)acetamide;
(2S)-2-phenyl-N-{(3aR,4R,6aS)-2-[(1S)-1-phenylethyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
(2S)-2-phenyl-N-{(3aR,4S,6aS)-2-[(1S)-1-phenylethyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
(2S)-2-phenyl-N-{(3aS,4S,6aR)-2-[(1S)-1-phenylethyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
(2S)-2-phenyl-N-{(3aS,4R,6aR)-2-[(1S)-1-phenylethyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N,3-dimethyl-2-phenylbutanamide;
N-[(3aS*,4R*,6aR*)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N,3-dimethyl-2-phenylbutanamide;
(3aR*,4S*,6aS*)-N-benzyl-2-(3-methyl-2-phenylbutanoyl)octahydrocyclopenta[c]pyrrol-4-amine;
2,2-dicyclohexyl-N-[(3aS,4R,6aR)-2-(N,N-dimethyl-D-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
N-[(3aR,4S,6aS)-2-benzoyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-2-phenylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N-isopropyl-N-phenylurea;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-(1,1-dioxidoisothiazolidin-2-yl)-4-methylpentanamide;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-ylcarbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(ethyl)carbamate;
tert-butyl (2S,3S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-3-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4,4-dimethyl-1-oxopentan-2-ylcarbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxo-hexan-2-yl(methyl)carbamate;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2,2-bis(4-fluorophenyl)acetamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-isopropyl-3-methylbutanamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methylbutanamide;
tert-butyl (2S)-2-({[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]amino}carbonyl)piperidine-1-carboxylate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-3-methyl-1-oxobutan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxo-pentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-2-isopropyl-3-methylbutanamide;
N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methylbutanamide;
2-cyclohexyl-2-hydroxy-N-{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}acetamide;
tert-butyl (S)-1-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxo-pentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxo-pentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
S-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -(methylsulfonyl)-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -(methylsulfonyl)-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -neopentyl-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -neopentyl-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -neopentyl-L-norvalinamide;
tert-butyl (S)-1-((3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4,4-dimethyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-ylamino)-4,4-dimethyl-1-oxopentan-2-yl(methyl)carbamate;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-2-morpholin-4-ylpentanamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-2-pyrrolidin-1-ylpentanamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-2-piperidin-1-ylpentanamide;
N 2 -neopentyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -neopentyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -neopentyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -neopentyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -neopentyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -neopentyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N-(tert-butoxycarbonyl)-N-methyl-N-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
N 2 -neopentyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -neopentyl-L-leucinamide;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(5-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
isopropyl (S)-1-oxo-1-((3aR,4S,6aS)-2-(5-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(6-(trifluoromethyl)pyridin-2-yl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
tert-butyl (S)-4,4-dimethyl-1-((3aR,4S,6aS)-2-(2-(methylsulfonyl)pyrimidin-5-yl)octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-ylcarbamate;
(S)-tert-butyl 2-((3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylcarbamoyl)pyrrolidine-1-carboxylate;
tert-butyl (1R)-1-isopropyl-3-oxo-3-[((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)amino]propylcarbamate;
tert-butyl (2S)-2-[((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)amino]carbonyl}piperidine-1-carboxylate;
N-(tert-butoxycarbonyl)-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
N-(tert-butoxycarbonyl)-N-methyl-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
(S)-tert-butyl 2-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylcarbamoyl)pyrrolidine-1-carboxylate;
tert-butyl (1R)-1-isopropyl-3-oxo-3-[((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)amino]propylcarbamate;
tert-butyl methyl((S)-3-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-yl)carbamate;
tert-butyl (2S)-2-{[((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)amino]carbonyl}piperidine-1-carboxylate;
tert-butyl (3S)-3-{[((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)amino]carbonyl}-3,4-dihydroisoquinoline-2 (1H)-carboxylate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)hexan-2-yl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
isopropyl (S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
isopropyl (S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
(3aS,4R,6aR)—N-neopentyl-2-{[3 (trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-neopentyl-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-isopropyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-N-isopropyloctahydrocyclopenta[c]pyrrol-4-amine;
(3aS,4R,6aR)—N-(4-fluorobenzyl)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-(4-fluorobenzyl)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-(4-fluorobenzyl)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-ethyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N,N-diethyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-propyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N,N-dipropyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-(cyclopropylmethyl)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-N-ethyloctahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-N,N-diethyloctahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}-N-[5-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-amine;
tert-butyl (S)-1-(ethyl((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-(propyl((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)amino)pentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((cyclopropylmethyl)((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)amino)-4,4-dimethyl-1-oxopentan-2-yl(methyl)carbamate;
2-nitro-N-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)benzenesulfonamide;
N-methyl-2-nitro-N-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)benzenesulfonamide;
(3aR,4S,6aS)—N-methyl-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
tert-butyl (S)-4,4-dimethyl-1-(methyl((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl)amino)-1-oxopentan-2-yl(methyl)carbamate;
(2S)-2-(1,1-dioxidoisothiazolidin-2-yl)-4-methyl-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}pentanamide;
2-isopropyl-3-methyl-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
2-isopropyl-3-methyl-N-{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}butanamide;
tert-butyl (S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-(4-fluorobenzyl) octahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl ethyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(3-fluoro-4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(4-fluoro-3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aR,4S,6aS)-2-(4-fluorobenzyl) octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-3-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-yl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl(methyl)carbamate;
(2S)-4-methyl-2-morpholin-4-yl-N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
(2S)-4-methyl-2-pyrrolidin-1-yl-N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
(2S)-4-methyl-2-piperidin-1-yl-N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tertbutyl ethyl((S)-4-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(4-fluorophenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(4-fluoro-3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-4-methyl-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4R,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-4-methyl-1-oxo-1-((3aR,4R,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-1-((3aS,4R,6aR)-2-(4-fluorophenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((2S,3S)-3-methyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((2S,3S)-3-methyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((2S,3S)-3-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((2S,3S)-3-methyl-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-3-methyl-1-oxo-1-((3aS,4R,6aR)-2-(3-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-yl)carbamate;
tert-butyl (S)-3,3-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-ylcarbamate;
tert-butyl (S)-3,3-dimethyl-1-oxo-1-((3aS,4R,6aR)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-ylcarbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)hexan-2-yl)carbamate;
tert-butyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
(2S)-4-methyl-2-pyrrolidin-1-yl-N-{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzoyl]octahydrocyclopenta[c]pyrrol-4-yl}pentanamide;
(2S)-4-methyl-N-[(3aS,4R,6aR)-2-(methylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-2-pyrrolidin-1-ylpentanamide;
(2S)—N-[(3aS,4R,6aR)-2-(cyclopropylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-2-pyrrolidin-1-ylpentanamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
tert-butyl methyl((S)-4-methyl-1-((3aS,4R,6aR)-octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl)carbamate;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]piperidine-2-carboxamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-valinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-isoleucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-isoleucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 , 4-dimethyl-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-L-valinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-methyl-L-valinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 ,4-dimethyl-L-leucinamide;
N 1 -[(3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 1 -[(3aS,4S,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norleucinamide;
N 1 -[(3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 1 -[(3aR,4R,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 2 -ethyl-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -methyl-N 1 -{(3aS,4R,6aR) 2 -[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-valinamide;
(2S)—N-[(3aS,4R,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]piperidine-2-carboxamide;
N 1 -[(3aS,4R,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -valinamide;
(2S)—N-{(3aS,4R,6aR)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}piperidine-2-carboxamide;
N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N 1 -[(3aS,4R,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-valinamide;
N 1 -{(3aS,4R,6aR)-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[4-fluoro-3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 2 -methyl-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N 2 -methyl-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N 1 -[(3aR,4S,6aS)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -methyl-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N 2 -ethyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)-phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
N-methyl-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-prolinamide;
(2S)-3-amino-4-methyl-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
(2S)—N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-piperidine-2-carboxamide;
(3S)—N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;
4-methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norleucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-prolinamide;
(3R)-3-amino-4-methyl-N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
(2S)—N-((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)piperidine-2-carboxamide;
(2S)—N-{(3aS,4R,6aR)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}piperidine-2-carboxamide;
N 1 -{(3aS,4R,6aR)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-valinamide;
(2S)—N-((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)piperidine-2-carboxamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
N 1 -{(3aS,4R,6aR)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
N 1 -((3aS,4R,6aR)-2-{[4-fluoro-3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -methyl-L-leucinamide;
3-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
3-methyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-isoleucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-isoleucinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-isoleucinamide;
N 2 -methyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-isoleucinamide;
N 2 ,4-dimethyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,4-dimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,4-dimethyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,4-dimethyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norleucinamide;
4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -methyl-N 1 -((3aR,4R,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aR,4R,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
3-cyclohexyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-alaninamide;
3-cyclohexyl-N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-alaninamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-4-methyl-L-leucinamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-4-methyl-L-leucinamide;
N-methyl-N-((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-phenylalaninamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N2,4-dimethyl-L-leucinamide;
N-((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N-methyl-L-phenylalaninamide;
N 1 -cyclopropyl-N 2 ,4-dimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -ethyl-N 2 ,4-dimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,4-dimethyl-N 1 -propyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -(cyclopropylmethyl)-N 2 ,4-dimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 ,N 2 ,4-trimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 ,N 2 -dimethyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 1 ,N 2 ,4-trimethyl-L-leucinamide;
4-methyl-N 1 -{(3aR,4S,6aS)-2-[5-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
4-methyl-N 1 -{(3aR,4S,6aS)-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
4-methyl-N 1 -{(3aR,4S,6aS)-2-[2-(methylsulfonyl)pyrimidin-5-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[(3-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[(3,4-difluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-yl-N 2 -methyl-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[(3,5-difluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 1 -{(3aS,4R,6aR)-2-[(4-chlorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 2 -methyl-N 1 -[(3aS,4R,6aR)-2-(phenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-L-leucinamide;
N 2 -methyl-N 1 -{(3aS,4R,6aR)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-(4-fluorobenzyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-valinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-valinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-4-methyl-L-leucinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norleucinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-leucinamide;
N 2 -methyl-N 1 -((3aS,4S,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aS,4S,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -{(3aR,4S,6aS)-2-[3,3-bis(4-fluorophenyl)propyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
2,2-bis-(4-fluorophenyl)-N-[(3aR,4S,6aS)-2-(N-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
2,2-bis(4-fluorophenyl)-N-[(3aR,4S,6aS)-2-(N-methyl-L-norvalyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
N-[(3aR,4S,6aS)-2-(N,4-dimethyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-2,2-bis(4-fluorophenyl)acetamide;
2,2-bis(4-fluorophenyl)-N-[(3aR,4S,6aS)-2-(4-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
tert-butyl (S)-1-((3aR,4S,6aS)-4-(S)-2-(tert-butoxycarbonylamino)-4,4-dimethylpentanamido)hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-4,4-dimethyl-1-oxopentan-2-yl-carbamate;
4-methyl-N 1 -[(3aR,4S,6aS)-2-(4-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-L-leucinamide;
4-methyl-N 1 -[(3aR,4S,6aS)-2-L-phenylalanyloctahydrocyclopenta[c]pyrrol-4-yl]-leucinamide;
(3aR,4S,6aS)—N-benzhydryl-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4R,6aR)—N-benzhydryl-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
(3aR,4S,6aS)—N-benzhydryl-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-amine;
N 1 -[(3aS,4R,6aR)-2-benzhydryloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-leucinamide;
4-methyl-N 2 -propyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(cyclopropylmethyl)-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(cyclobutylmethyl)-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -isobutyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(cyclopentylmethyl)-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(cyclohexylmethyl)-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -butyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -ethyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(cyclopropylmethyl)-4-methyl-N 1 -{(3aR,4S,6aS)-2-[5-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(cyclopropylmethyl)-4-methyl-N 1 -{(3aR,4S,6aS)-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -isopropyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -isopropyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -isopropyl-N 1 -((3aS,4R,6aR)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -isopropyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -isopropyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
3-cyclohexyl-N 2 -isopropyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-alaninamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -isopropyl-4-methyl-L-leucinamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -isopropyl-4-methyl-L-leucinamide;
N 2 -isopropyl-N 1 -[(3aR,4S,6aS)-2-(N-isopropyl-4-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-L-leucinamide;
N 2 -isopropyl-N 1 -[(3aR,4S,6aS)-2-(N-isopropyl-L-phenylalanyl)octahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-L-leucinamide;
N 2 -isopropyl-4-methyl-N 1 -{(3aR,4S,6aS)-2-[5-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -isopropyl-4-methyl-N 1 -{(3aR,4S,6aS)-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
2,2-bis(4-fluorophenyl)-N-[(3aR,4S,6aS)-2-(N-isopropyl-4-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]acetamide;
N 2 -isopropyl-4-methyl-N 1 -{(3aR,4S,6aS)-2-[2-(methylsulfonyl)pyrimidin-5-yl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -isopropyl-L-norvalinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -isopropyl-L-norvalinamide;
N 2 -isopropyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,N 2 -dimethyl-N 1 -((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
(3R)-3-(dimethylamino)-4-methyl-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
N 2 -cyclopropyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 ,N 2 -dicyclopropyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -cyclopentyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -cyclohexyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -(1-ethylpropyl)-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -cyclobutyl-4-methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
4-methyl-N 2 -neopentyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 2 -cyclopentyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -cyclohexyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -cyclopentyl-N 1 -[(3aR,4S,6aS)-2-(N-cyclopentyl-4-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-4-methyl-L-leucinamide;
N 2 ,N 2 -dimethyl-N 1 -{(3aS,4S,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-N 2 -neopentyl-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -(3,3-dimethylbutyl)-N 2 -methyl-L-leucinamide;
N 2 ,N 2 -dimethyl-N 1 -((3aS,4R,6aR)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-leucinamide;
N 1 -[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N 2 -(4-fluorobenzyl)-N 2 -methyl-L-leucinamide;
(2S)—N-[(3aS,4R,6aR)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-1-(methylsulfonyl)piperidine-2-carboxamide;
(3R)-4-methyl-3-[(methylsulfonyl)amino]-N-((3aR,4S,6aS)-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)pentanamide;
N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-D-leucinamide;
N 2 -ethyl-N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
4-methyl-N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
3-methyl-N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-valinamide;
N 2 -(methylsulfonyl)-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N 2 -(isopropylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(phenylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
N 2 -(cyclopentylsulfonyl)-N 1 -{(3aS,4R,6aR)-2-[3-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-leucinamide;
isopropyl (S)-4,4-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
isopropyl (S)-3,3-dimethyl-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)butan-2-ylcarbamate;
cyclopentyl (S)-1-oxo-1-((3aR,4S,6aS)-2-(4-(trifluoromethyl)benzyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-ylcarbamate;
N 2 -(2,2-dimethylpropanoyl)-N 1 -{(3aR,4S,6aS)-2-[4-(trifluoromethyl)benzyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
tert-butyl (S)-1-((3aR,4S,6aS)-2-(3-chloro-4-fluorophenylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)-1-oxopentan-2-yl(methyl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(pyridin-3-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
tert-butyl methyl((S)-1-oxo-1-((3aR,4S,6aS)-2-(thiophen-2-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-ylamino)pentan-2-yl)carbamate;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethoxy)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -[(3aR,4S,6aS)-2-(thien-2-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(3-chloro-4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -[(3aR,4S,6aS)-2-(pyridin-3-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-cyanophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-methoxyphenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[3,5-bis(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(2-chloro-4-fluorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -[(3aR,4S,6aS)-2-(1-naphthylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[4-bromo-3-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(3,4-dichlorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(4-tert-butylphenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -[(3aR,4S,6aS)-2-(1,1′-biphenyl-4-ylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(3,4-dimethoxyphenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(3-cyanophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -[(3aR,4S,6aS)-2-(2-furylsulfonyl)octahydrocyclopenta[c]pyrrol-4-yl]-N 2 -methyl-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(2,3-dichlorophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[4-(trifluoromethyl)benzyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 2 -methyl-N 1 -((3aR,4S,6aS)-2-{[2-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-L-norvalinamide;
N 1 -{(3aR,4S,6aS)-2-[(3-bromophenyl)sulfonyl]octahydrocyclopenta[c]pyrrol-4-yl}-N 2 -methyl-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-4-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -methyl-L-norvalinamide;
N 1 -((3aR,4S,6aS)-2-{[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}octahydrocyclopenta[c]pyrrol-4-yl)-N 2 -methyl-L-norvalinamide;
N 2 -methyl-N 1 -{(3aR,4S,6aS)-2-[3-(trifluoromethyl)benzoyl]octahydrocyclopenta[c]pyrrol-4-yl}-L-norvalinamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-N-isopropyl-3-(trifluoromethyl)benzenesulfonamide;
N-[(3aR,4S,6aS)-2-benzyloctahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
N-isopropyl-N-[(3aR,4S,6aS)-2-(N-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
N-[(3aR,4S,6aS)-2-(N-methyl-L-leucyl)octahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide;
N-cyclopropyl-N-[(3aS*,4S*,6aR*)-[2-(N-methyl-L-leucyl) octahydrocyclopenta[c]pyrrol-4-yl]-3-(trifluoromethyl)benzenesulfonamide; and
4-fluoro-N-{(3aR,4S,6aS)-2-[6-(trifluoromethyl)pyridin-2-yl]octahydrocyclopenta[c]pyrrol-4-yl}benzamide.
19. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.
20. A method of treating pain in a subject in need thereof, comprising: administering to the subject a therapeutically suitable amount of a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, wherein the pain is acute pain, chronic pain, neuropathic pain, inflammatory pain, visceral pain, cancer pain, allodynia, fibromyalgia, sciatica, back pain, and headache pain including migraine, or combinations thereof.