Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-amine

1. A compound of formula (I)

where:

Het is a heteroaryl group selected from the group consisting of pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl, said heteroaryl group being optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of: C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy and cyano;

R 1 is C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1- 4 alkoxy, cyano, C 1-4 alkylSO 2 , C 3-8 cycloalkylSO 2 , C 3-8 cycloalkylCH 2 SO 2 , phenyl or a 5 or 6 membered heterocyclyl group containing 1, 2 or 3 atoms selected from N, O or S, which phenyl or heterocyclyl group is optionally substituted with C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy or cyano;

R 2 is C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy, cyano, phenyl or a 5 or 6 membered heterocyclyl group containing 1, 2 or 3 atoms selected from N, O or S, which phenyl or heterocyclyl group is optionally substituted with C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy or cyano;

R 3 is C 1-4 alkyl, halo, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy or cyano;

m is 0 or 1; and

n is 0 or 1;

or a pharmaceutically acceptable salt thereof.

2. The compound or salt according to claim 1 , where Het is pyrimidinyl.

3. The compound or salt according to claim 1 , where m is 0 and n is 0.

4. The compound or salt according to claim 1 , where m is 1 and n is 0.

5. The compound or salt according to claim 1 , where R 1 is CH 3 .

6. The compound or salt according to claim 1 , where Het is pyridinyl substituted with trifluoromethyl, m is 1, n is 0, R 1 is CH 3 and R 2 is pyrimidinyl.

7. The compound or salt according to claim 1 , where Het is pyrazinyl substituted with trifluoromethyl, m is 1, n is 0, R 1 is CH 3 and R 2 is pyrimidinyl.

8. The compound or salt according to claim 1 , where Het is substituted with haloC 1-4 alkyl.

9. The compound or salt according to claim 8 , where Het is substituted with trifluoromethyl.

10. The compound or salt according to claim 1 , where Het is pyridinyl.

11. The compound or salt according to claim 10 , where Het is pyridinyl substituted with trifluoromethyl or cyano.

12. The compound or salt according to claim 1 , where R 2 is methoxy, ethoxy, propoxy, phenyl, pyrimidinyl, oxadiazolyl, oxazolyl, isoxazolyl, thiazolyl, triazolyl, imidazolyl, pyrazolinyl, pyridazinyl, pyrazinyl or pyridinyl.

13. The compound or salt according to claim 12 , where R 2 is pyrimidinyl.

14. A pharmaceutical composition comprising the compound or salt according to claim 1 and one or more pharmaceutically acceptable carriers.

15. A compound selected from the group consisting of:

N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3 -azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine;

N-[((1S,4S,6S)-3-{[3-(ethyloxy)-6-methyl-2-pyridinyl]carbonyl}-3 -azabicyclo [4.1.0]hept-4-yl)methyl]-5 -(trifluoromethyl)-2-pyridinamine;

N-[((1S,4S,6S)-3-{[6-methyl-3-(2-pyrimidinyl)-2-pyridinyl]carbonyl}-3 -azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine;

N-[((1S,4S,6S)-3-{[6-methyl-3-(2-pyrimidinyl)-2-pyridinyl]carbonyl}-3-azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyrazinamine;

N-[((1 S,4S,6S)-3-{[6-methyl-3-(1H-pyrazol-1-yl)-2-pyridinyl]carbonyl}-3-azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyrazinamine; and

N-[((1S,4S,6S)-3-{[6-methyl-3-(2H-1,2,3-triazol-2-yl)-2-pyridinyl]carbonyl}-3-azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyrazinamine;

or a pharmaceutically acceptable salt thereof.

16. A pharmaceutical composition comprising the compound or salt according to claim 15 and one or more pharmaceutically acceptable carriers.