Methods of treating rheumatoid arthritis
View Patent ↗Imidazole-based compounds, compositions comprising them, and methods of their use for the treatment, prevention and management of inflammatory and autoimmune diseases and disorders are disclosed. Particular compounds are of formula I:
1. A method of treating or managing rheumatoid arthritis, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is lower alkyl;
R 3 is hydrogen, OR 3A , NHC(O)R 3A or NHSO 2 R 3A ;
R 9 is hydrogen or CH 2 OH; and
each R 3A is independently hydrogen or lower alkyl.
2. The method of claim 1 , wherein the compound is of the formula:
3. The method of claim 2 , wherein R 3 is OR 3A .
4. The method of claim 3 , wherein R 3A is hydrogen.
5. A method of treating or managing rheumatoid arthritis, which comprises administering to a patient in need thereof a therapeutically effective amount of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)-ethanone oxime.