Tasted masked veterinary solid compositions
View Patent ↗The present invention relates to the supply and production of an animal medicine consisting of a substrate in pellet or tablet form, which is attractive to livestock and domestic animals, in which fine-grained particles of a neutral-tasting, physiologically compatible, solid carrier material are embedded, which is characterized in that said fine-grained particles of carrier material have an average diameter of 0.09 to 0.8 mm and are coated with an active substance from veterinary medicine, and said active substance layer is covered with a protective layer of a physiologically compatible polymer matrix, and to the production of this animal medicine. It also relates to the usage of said double-coated, fine-grained particles of carrier material in the production of a preparation for veterinary medicine.
1. A composition for consumption by a dog comprising:
an animal feed substrate which is yeast; and
one or more coated particles, wherein said substrate and said coated particles are intimately mixed and pressed into tablets or pellets of suitable size for feed consumption by a dog, said intimate mixture of substrate and coated particles optionally comprising one or more additives selected from the group consisting of proteins, vitamins, minerals, artificial aromatics, and natural aromatics and wherein said coated particles consist of:
a carrier material having an average diameter of approximately 0.09 mm to 0.8 mm, wherein said carrier material is cellulose;
a first coat which is a casing consisting of benazepril and polyvinyl pyrrolidone; and
a second coat comprising a physiologically compatible cationic polymer matrix, wherein said physiologically compatible cationic polymer matrix is an acrylic acid polymer or a methacrylic acid polymer or a combination of said polymers.
2. The composition of claim 1 wherein the carrier material has an average diameter of approximately 0.15 mm to 0.4 mm.
3. The composition of claim 1 wherein the cationic polymer is based on diaminoethyl methacrylate and neutral methacrylic esters.
4. A method of making the composition of claim 1 , said method comprising:
mixing benazepril with a solvent;
coating a carrier material with the benazepril dissolved in a solvent, wherein said carrier material has an average diameter of approximately 0.09 mm to 0.8 mm, and wherein said carrier material is cellulose;
coating said benazepril-coated carrier material with an additional cationic masking protective layer to form multi-coated particles, wherein said cationic masking protective layer is an acrylic add polymer or a methacrylic acid polymer or a combination of said polymers;
intimately mixing said multi-coated particles with a substrate wherein said substrate consists of yeast; and
compressing said intimately mixed coated particles and substrate into tablets or pellets of appropriate size for feed consumption.
5. The method of claim 4 further comprising adding one or more additives to said intimately mixed coated particles and substrate wherein said additive is selected from the group consisting of proteins, vitamins, minerals, artificial aromatic substances, and natural aromatic substances.
6. The method of claim 4 wherein the carrier material has an average diameter of approximately 0.15 mm to 0.4 mm.
7. The method of claim 4 wherein the cationic polymer is based on dimethylaminoethyl methacrylate and neutral methacrylic esters.