Preventing transfusion related complications in a recipient of a blood transfusion
View Patent ↗This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.
1. A process for reducing rejection of a donor organ by a recipient comprising the steps of:
transfusing the recipient of the donor organ with platelets treated with a photosensitizer consisting essentially of riboflavin at a concentration of 50 μM and light at a wavelength between 290-370 nm for around 8 minutes,
wherein the recipient is transfused with the treated platelets for a period of time before receiving the donor organ; and
transplanting the donor organ into the recipient.
2. The process of claim 1 wherein the step of transfusing is repeated multiple times before the organ transplant.
3. The process of claim 1 wherein the donor organ to be transplanted into the recipient is allogeneic.
4. The process of claim 1 wherein the donor organ to be transplanted into the recipient is xenogeneic.
5. The process of claim 1 wherein the treated platelets are from an allogeneic donor.
6. The process of claim 1 wherein the treated platelets reduce the development of antibodies to the transplanted organ in the transplant recipient.
7. The process of claim 1 wherein the donor organ is a solid organ.
8. The process of claim 7 wherein the donor organ is a heart.