Intermediate compounds for the preparation of
View Patent ↗Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]pyrrole.
1. A process for preparing a trans-amino acid derivative of formula I,
the process comprising reacting a mixture of lactams of formula IV and Formula V,
with a base in the presence of an alcohol.
2. A process for preparing a trans-amino acid derivative of formula II,
the process comprising reacting a mixture of lactams of formula VII and formula VIII,
with a base in the presence of an alcohol.
3. The process of claim 1 , wherein the base is an alkaline base that is present in stoichiometric excess, and the alcohol is a C1 to C6 alkanol.
4. The process of claim 2 , wherein the base is an alkaline base that is present in stoichiometric excess, and the alcohol is a C1 to C6 alkanol.
5. The process of claim 1 , wherein the base is potassium hydroxide and the alcohol is ethanol.
6. The process of claim 2 , wherein the base is potassium hydroxide and the alcohol is ethanol.