Multicyclic compounds and methods of their use
This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.
1. A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein:
each of E 1 , E 2 and E 3 is independently N or CR 2 ;
each of G 1 and G 2 is independently N or CR 3 ;
each of R 1 , R 2 and R 3 is independently hydrogen, halogen, cyano, R A , OR A , C(O)R A , C(O)OR A , C(O)N(R A R B ), N(R A R B ), or SO 2 R A ;
each R 5 is independently halogen, cyano, R A , OR A , C(O)R A , C(O)OR A , C(O)N(R A R B ), N(R A R B ), or SO 2 R A ;
each R A is independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, alkylaryl, heterocycle, heterocycle-alkyl, or alkyl-heterocycle;
each R B is independently hydrogen or optionally substituted alkyl, aryl, arylalkyl, alkylaryl, heterocycle, heterocycle-alkyl, or alkyl-heterocycle; and
n is 0-5.
2. The compound of claim 1 , wherein G 1 is N.
3. The compound of claim 1 , wherein G 2 is N.
4. The compound of claim 1 , wherein G 1 and G 2 are both N.
5. The compound of claim 1 , wherein each R 1 is hydrogen.
6. The compound of claim 1 , wherein E 1 is CR 2 .
7. The compound of claim 1 , wherein E 2 is CR 2 .
8. The compound of claim 1 , wherein E 3 is CR 2 .
9. The compound of claim 1 , wherein E 1 , E 2 and E 3 are all CR 2 .
10. The compound of claim 9 , wherein E 1 , E 2 and E 3 are all CH.
11. The compound of claim 10 , wherein at least one R 2 is halo.
12. The compound of claim 11 , wherein one of R 2 is chloro.
13. The compound of claim 1 , wherein n is 0.
14. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is (3′-chlorobiphenyl-4-yl)(1-(pyrimidin-2-yl)piperidin-4-yl)methanone.
15. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable excipient.
16. A capsule or tablet comprising the pharmaceutical composition of claim 15 .
17. A pharmaceutical composition comprising a compound of claim 14 and a pharmaceutically acceptable excipient.
18. A capsule or tablet comprising the pharmaceutical composition of claim 17 .