15-OXA-steroid compounds
View Patent ↗The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5 -ene-3β-yl)-β-D-glucopyranosiduronate, 16α,3α-dihydroxy-5α-androstan-17-one or 3,7,16,17 -tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17 -tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
1. A compound having the structure
wherein the dotted line is an optional double bond;
wherein when Δ 5 double bond is present, —H at position-5 is absent or when Δ 5 double are bond is absent, —H at position-5 is in the α- or β-configuration.
R 1 , R 2 and R 4 independently are —OH, an ester or an ether;
R 3 is —H, —OH, an ester, an ether or halogen;
R 5 is —CH 3 or —CH 2 OH;
R 6 is —CH 3 ;
and R 7 is —O—.
2. The compound of claim 1 wherein R 1 , R 2 and R 4 are —OH or an ester and R 3 is —OH, an ester or —Br.
3. The compound of claim 2 wherein R 5 is —CH 3 .
4. The compound of claim 1 wherein the compound has the formula
5. The compound of claim 4 wherein R 1 , R 2 and R 4 are —OH or an ester and R 3 is —OH, an ester or —Br.
6. The compound of claim 5 wherein R 5 is —CH 3 .
7. The compound of claim 4 wherein the compound has the structure
8. The compound of claim 7 wherein R 1 , R 2 and R 4 are —OH and R 3 is —OH or —Br.
9. The compound of claim 1 wherein the compound has the formula
10. The compound of claim 9 wherein R 1 , R 2 and R 4 are —OH or an ester and R 3 is —OH, an ester or —Br.
11. The compound of claim 10 wherein R 5 is —CH 3 .
12. The compound of claim 9 wherein the compound has the structure
13. The compound of claim 12 wherein R 1 , R 2 and R 4 are —OH and R 3 is —OH or —Br.
14. The compound of claim 4 wherein the compound has the structure
15. The compound of claim 9 wherein the compound has the structure