Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration
Composition of biocompatible microparticles of alginic acid for the controlled release of active ingredients by intravenous administration. The invention relates to a biocompatible composition which comprises microparticles of alginic acid or its salts and an active ingredient. More particularly, the invention relates to microparticles for the encapsulation of an active ingredient to be administered intravenously to a patient who needs it. These microparticles are of a combination of size sufficient to increase the half-life or survival of the active ingredient in blood, with a low uptake in the liver and a fast cell clearance when administered intravenously.
1. A biocompatible composition for intravenous administration comprising microparticles of alginic acid or salt thereof less than or equal to 5 μm in size and having a negative Z potential, and wherein the alginic acid or salt thereof is complexed with a therapeutic active ingredient.
2. A composition according to claim 1 , wherein the size of the microparticles is between 1 and 4.5 μm.
3. A composition according to claim 1 , wherein the Z potential is between −70 and 0, not including 0.
4. A composition according to claim 1 , wherein the active ingredient is a peptide, a protein or a hormone.
5. A composition according to claim 4 , wherein the active ingredient is of human, animal, recombinant or transgenic origin.
6. A composition according to claim 4 , wherein the active ingredient exhibits labile biological activity.
7. A composition according to claim 4 , wherein the active ingredient is a blood clotting factor.
8. A composition according to claim 4 , wherein the active ingredient is factor VIII.
9. A composition according to claim 4 , wherein the active ingredient is VWF.
10. A composition according to claim 4 , wherein the active ingredient is the complex formed by FVIII and VWF.
11. A composition according to claim 4 , wherein the active ingredient is factor IX.
12. A composition according to claim 4 , wherein the active ingredient is factor VIIa.