Methods of reducing hair loss and/or facilitating hair growth and/or regrowth
View Patent ↗The present disclosure relates to methods of retarding hair loss or facilitating hair growth and/or regrowth. More specifically, the present disclosure relates to methods of using the disclosed compositions to increase the rate of terminal hair growth and/or regrowth in a mammal.
1. A method of reducing hair loss and/or facilitating hair growth or hair regrowth comprising the steps of applying to skin of a mammal in need of such treatment a safe and effective amount of a composition comprising from about 0.1% to about 100% by weight of an admixture, comprising:
a. from about 0.01% to about 99.98% by weight of the admixture of an acid selected from the group consisting of intermediates of the Kreb cycle, non-Kreb cycle intermediate alpha-keto acid, derivatives thereof, salts thereof and mixtures thereof;
b. from about 0.01% to about 99.98% by weight of the admixture of an antioxidant; and
c. from about 0.01% to about 99.98% by weight of the admixture of a fatty acid mixture or fatty acid mixture source comprising at least 7 unsaturated or saturated fatty acids selected from the group consisting of butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, gadoleic acid, pentadecanoic acid, margaric acid, margaroleic acid, behenic acid, dihomolinoleic acid, arachidonic acid and lignoceric acid.
2. The method of claim 1 , wherein the acid is an alpha-keto acid.
3. The method of claim 1 , wherein the alpha-keto acid is selected from the group consisting of pyruvic acid, alpha-ketoglutaric acid, alpha-ketoisovaleric acid, alpha-ketoisocaproic acid, salts thereof and mixtures thereof.
4. The method according to claim 3 , wherein the alpha-keto acid is a pyruvic acid selected from the group consisting of pyruvic acid, lithium pyruvate, sodium pyruvate, potassium pyruvate, magnesium pyruvate, calcium pyruvate, zinc pyruvate, manganese pyruvate, methyl pyruvate, salts thereof, prodrugs thereof, and mixtures thereof.
5. The method according to claim 4 , wherein the pyruvic acid is sodium pyruvate.
6. The method according to claim 1 , wherein the antioxidant is selected from the group consisting of a Vitamin A; a Vitamin C; a tocopherol; prodrugs of Vitamin A, prodrugs of Vitamin C, and prodrugs of Vitamin E; salts of Vitamin A, salts of Vitamin C, and salts of Vitamin E; flavonoids; polyphenols; and mixtures thereof.
7. The method according to claim 6 , wherein the antioxidant is a Vitamin E selected from the group consisting of alpha-tocopherol, beta-tocopherol, gamma-tocopherol, delta-tocopherol, tocoquinone, tocotrienol, esters thereof and mixtures thereof.
8. The method according to claim 7 , wherein the Vitamin E is selected from the group consisting of esters of tocopherol, esters of beta-tocopherol, esters of gamma-tocopherol, esters of delta-tocopherol, esters of tocoquinone, esters of tocotrienol and mixtures thereof.
9. The method according to claim 8 , wherein the Vitamin E is selected from the group consisting of an acetate ester of tocopherol, acetate ester of beta-tocopherol, acetate ester of gamma-tocopherol, acetate ester of delta-tocopherol, acetate ester of tocoquinone, acetate ester of tocotrienol and mixtures thereof.
10. The method according to claim 1 wherein the fatty acids are present in the fatty acid mixture by weight as follows: about 0.2%-0.4% butyric acid, about 0.1% caproic acid, about 0.3%-0.8% caprylic acid, about 2.2%-3.5% capric acid, about 0.9%-5.5% lauric acid, about 2.8%-8.5% myristic acid, about 0.1%-0.6% myristoleic acid, about 23.2%-24.6% palmitic acid, about 1.8%-3.0% palmitoleic acid, about 6.9%-9.9% stearic acid, about 36.0%-36.5% oleic acid, about 20%-20.6% linoleic acid, about 7.5-7.8% linolenic acid, about 1.1%-4.9% arachidic acid, and about 3.3%-6.4% gadoleic acid.
11. The method according to claim 1 wherein the fatty acids are present in the fatty acid mixture by weight as follows: about 0.3% myristic acid, about 19% palmitic acid, about 0.5% palmitoleic acid, about 13% stearic acid, about 44.4% oleic acid, about 21.3% linoleic acid, and about 0.5% linolenic acid.
12. The method according to claim 1 , being in the form of a suitable topical carrier.
13. The method according to claim 12 , wherein the topical carrier is in the form of an ointment, paste, gel, jelly, serum, aerosol spray, non-aerosol spray, foam, cream, lotion, solution, suspension.
14. The method according to claim 13 , wherein the composition is in the form of a lotion or suspension.