Refill of implantable fluid delivery devices based on therapeutic fluid expiration

1. A method comprising:

determining a refill interval for a therapeutic fluid delivered by a fluid delivery device based on an expiration time for the therapeutic fluid; wherein the expiration time comprises a period of time prescribed by a clinician; and generating a refill indication based on the refill interval.

2. The method of claim 1 , wherein generating a refill indication comprises generating a refill alarm upon expiration of the refill interval.

3. The method of claim 1 , wherein generating a refill indication comprises generating a refill alarm in advance of expiration of the refill interval.

4. The method of claim 1 , wherein the expiration time comprises a stability time for the therapeutic fluid.

5. The method of claim 1 , further comprising determining a modified expiration time based on one or more environmental conditions under which the therapeutic fluid is stored and determining the refill interval for the therapeutic fluid delivered by the fluid delivery device based on the modified expiration time for the therapeutic fluid.

6. The method of claim 1 , further comprising determining a modified expiration time based on a shelf-life of the therapeutic fluid and determining the refill interval for the therapeutic fluid delivered by the fluid delivery device based on the modified expiration time for the therapeutic fluid.

7. The method of claim 1 , wherein the expiration time comprises a period of time prescribed by a manufacturer of the fluid delivery device based on empirical data for the therapeutic fluid.

8. The method of claim 1 , wherein generating the refill indication comprises generating an alarm comprising one of an audible, tactile, or visual alert.

9. The method of claim 1 , wherein generating the refill indication comprises vibrating the fluid delivery device.

10. The method of claim 1 , wherein determining a refill interval for a therapeutic fluid delivered by a fluid delivery device based on an expiration time for the therapeutic fluid comprises:

determining a refill interval based on a volume of the therapeutic fluid to be stored in the fluid delivery device;

comparing the fluid volume based refill interval to the expiration time;

and at least one of setting the refill interval for the therapeutic fluid to the lesser of the fluid volume based refill interval and the expiration time or displaying the volume based refill interval and the expiration time.

11. The method of claim 1 , wherein the fluid delivery device is at least partially implantable.

12. The method of claim 1 , wherein the fluid delivery device comprises a fluid delivery pump and an implantable catheter connected to the fluid delivery pump and configured to deliver the therapeutic fluid to a patient.

13. The method of claim 12 , wherein the fluid delivery pump comprises one of an external or implantable fluid delivery pump.

14. A method comprising:

determining a refill interval for a therapeutic fluid delivered by a fluid delivery device based on an expiration time for the therapeutic fluid; and

generating a refill indication based on the refill interval, wherein generating the refill indication comprises vibrating the fluid delivery device.

15. A method comprising:

determining a refill interval for a therapeutic fluid delivered by a fluid delivery device based on an expiration time for the therapeutic fluid; wherein determining the refill interval comprises determining the refill interval based on a volume of the therapeutic fluid to be stored in the fluid delivery device; comparing the fluid volume based refill interval to the expiration time; and at least one of setting the refill interval for the therapeutic fluid to the lesser of the fluid volume based refill interval and the expiration time or displaying the volume based refill interval and the expiration time; and

generating a refill indication based on the refill interval.