Packaging solutions
View Patent ↗Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed.
1. A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
(a) providing an ophthalmic device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) an ophthalmic device-forming comonomer;
(b) immersing the ophthalmic device in an aqueous packaging solution comprising a hydrophilic reactive polymer having complementary reactive functionalities aloneg the polymer chain, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;
(c) packaging the solution and the ophthalmic device in a manner preventing contamination of the device by microorganisms; and
(d) sterilizing the packaged solution and ophthalmic device
wherein the hydrophilic reactive polymer is a copolymer derived from 2-vinyl-4,4-dimethyl-2-oxazolin-5-one and dimethylacrylamide.
2. A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
(a) providing an ophthalmic device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) an ophthalmic device-forming comonomer;
(b) immersing the ophthalmic device in an aqueous packaging solution comprising a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the solution has an osmolality of at least about 200 mOsm/k and a pH in the range of about 6 to about 9;
(c) packaging the solution and the ophthalmic device in a manner preventing contamination of the device by microorganisms; and
(d) sterilizing the packaged solution and ophthalmic device
wherein the hydrophilic reactive polymer is selected from the group consisting of glycerol (meth)acrylate, erythritol (meth)acrylate, xylitol (meth)acrylate, sorbitol (meth)acrylate and mixtures thereof.
3. A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
(a) providing an ophthalmic device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) an ophthalmic device-forming comonomer;
(b) immersing the ophthalmic device in an aqueous packaging solution comprising a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;
(c) packaging the solution and the ophthalmic device in a manner preventing contamination of the device by microorganisms; and
(d) sterilizing the packaged solution and ophthalmic device
wherein the hydrophilic reactive polymer comprises monomeric units of glyceryl (meth)acrylate and monomeric units of (meth)acrylic acid.
4. A method of preparing a package comprising a storable, sterile ophthalmic device, the method comprising:
(a) providing an ophthalmic device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) an ophthalmic device-forming comonomer;
(b) immersing the ophthalmic device in an aqueous packaging solution comprising a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH in the range of about 6 to about 9;
(c) packaging the solution and the ophthalmic device in a manner preventing contamination of the device by microorganisms; and
(d) sterilizing the packaged solution and ophthalmic device
wherein the hydrophilic reactive polymer comprises monomeric units of vinyl alcohol and monomeric units of vinyl-pyrrolidone.