Bioactive antibacterial bone graft materials
View Patent ↗The present invention generally relates to bioactive antibacterial materials and composites that enhance bone growth while preventing surgical site infection. The present invention also relates to bioactive antibacterial materials and composites that include a bimodal bioactive glass particle size distribution. The bioactive antibacterial composite finds utility in a variety of clinical applications including spine and orthopaedic procedures.
1. A bioactive antibacterial composite comprising a biocompatible polymer, a porous calcium phosphate and a bioactive glass, wherein the bioactive glass consists of:
(a) particles having a particle size of less than about 53 microns (μm) and
(b) particles having a particle size range from about 90 microns (μm) to about 150 microns (μm),
wherein the biocompatible polymer is present in an amount from about 10% to about 20% by weight of the composite, the calcium phosphate is present in an amount from about 50% to about 75% by weight of the composite and the bioactive glass is present in an amount from about 10% to about 35% by weight of the composite, and
wherein the bioactive antibacterial composite has antibacterial efficacy of greater than about 3.7 log reduction at 1 day when tested based on USP <51> standard at a bioactive glass concentration of between about 50 to about 200 mg/mL.
2. The bioactive antibacterial composite of claim 1 , wherein the biocompatible polymer is collagen.
3. The bioactive antibacterial composite of claim 1 , wherein the calcium phosphate is beta-tricalcium phosphate.
4. The bioactive composite of claim 1 , wherein the bioactive glass is 45S5 or Combeite.
5. The bioactive antibacterial composite of claim 1 , wherein the composite has a total porosity of at least 30% and interconnected macro-, meso- and microporosity.
6. The bioactive antibacterial composite of claim 1 , wherein the biocompatible polymer is collagen and the calcium phosphate is beta-tricalcium phosphate.
7. A bioactive antibacterial composite comprising a biocompatible polymer, a porous calcium phosphate and a bioactive glass, wherein about 50% by weight of the bioactive glass comprises particles with a particle size of less than about 53 μm and about 50% by weight of the bioactive glass comprises particles having a particle size range from about 90 μm to about 150 μm, wherein the bioactive antibacterial composite has antibacterial efficacy of greater than about 3.7 log reduction at 1 day when tested based on USP <51> standard at a bioactive glass concentration of between about 50 to about 200 mg/mL.
8. A method for repairing a defect in bone and preventing surgical site infection comprising the step of administering the bioactive antibacterial composite of claim 1 or 7 to the bone.
9. The method of claim 8 , wherein the defect is a defect in the spine.
10. The method of claim 8 , wherein the defect is a defect in the vertebral body.
11. A method for repairing a damaged bone or tooth comprising placing the bioactive antibacterial composite of claim 1 or 7 in the bone or jaw.
12. The bioactive antibacterial composite of claim 7 , wherein the biocompatible polymer is collagen.
13. The bioactive antibacterial composite of claim 7 , wherein the calcium phosphate is beta-tricalcium phosphate.
14. The bioactive composite of claim 12 , wherein the bioactive glass is 45S5 or Combeite.
15. The bioactive antibacterial composite of claim 7 , wherein the composite has a total porosity of at least 30% and interconnected macro-, meso- and microporosity.
16. The bioactive antibacterial composite of claim 7 , wherein the biocompatible polymer is collagen and the calcium phosphate is beta-tricalcium phosphate.