Method of ameliorating symptoms of type 1-diabetes using GABA related compounds and GLP-1/exendin-4 compounds
A composition for the prevention or treatment of type I diabetes in a subject, said composition comprising a GABAergic and incretin exemplified by GABA and GLP-1/Ex4. These are optionally provided together in a single composition to promote beta-cell regeneration prevent beta-cell apoptosis and control autoimmunity for the prevention and treatment of T1D in mammals.
1. A method of ameliorating symptoms of type 1 diabetes (T1D), said method comprising administering a composition comprising an effective amount of:
a. gamma-amino butyric acid (GABA) or a pharmaceutically acceptable salt thereof; and
b. exendin-4 (Ex4) of SEQ ID NO:2.
2. The method at claim 1 , wherein said composition is administered by a method selected from topical administration, oral administration, aerosol administration, intraperitoneal injection, intravenous injection and/or intramuscular injection.
3. The method of claim 1 , wherein the dosage of the composition is 0.01-10 mmol of GABA per kg body weight and 0.02 to 1000 nmol of the Ex4 per kg body weight.
4. The method of claim 1 , wherein the dosage of the composition is between about 0.002-2 mg of GABA per kg body weight and 0.2-1000 nmol of the Ex4 per kg body weight.