Implantable suction cup composites and implants comprising same
View Patent ↗Described herein are implantable composites, kits comprising the composites, implant devices comprising the composites, and methods of making and using same, including point of use methods.
1. An implantable composite comprising: a deformable suction cup member, wherein the suction cup member comprises a biodegradable biocompatible polymer and a bioactive agent dispersed within the polymer, and wherein the suction cup member defines cavity and has a substantially planar rim, the bioactive agent comprising at least one of an antibiotic, antimicrobial, a growth factor, a growth inhibitor, an immunomodulator, a steroid, or an anti-inflammatory; the biodegradable biocompatible polymer comprising one or more residues selected from the group of lactide, glycolide, and caprolactone; the biodegradable biocompatible polymer exhibiting a mechanical property which enables the cup member to be deformed when contacting a contact surface.
2. The implantable composite of claim 1 , wherein the rim has a shape that is substantially circular, substantially rectangular, or substantially elliptical.
3. The implantable composite of claim 1 , wherein the suction cup member further comprises an opacifier.
4. The implantable composite of claim 1 , wherein the bioactive agent is encapsulated within a microparticle.
5. The implantable composite of claim 1 , wherein the substantially planar rim further comprises an adhesive.
6. The implantable composite of claim 5 , wherein the adhesive comprises a biodegradable adhesive.
7. The implantable composite of claim 6 , wherein the biodegradable adhesive comprises poly(lactide-co-caprolactone), poly(glycolide-co-caprolactone), or combinations, and mixtures, and blends thereof.
8. The implantable composite of claim 1 , the suction cup member comprising a terpolymer.
9. An implant device comprising:
an implantable composite; wherein the implantable composite comprises a deformable suction cup member comprising a biodegradable biocompatible polymer and a bioactive agent dispersed within the polymer; wherein the suction cup member defines a cavity and has a substantially planar rim, the bioactive agent comprising at least one of an antibiotic, antimicrobial, a growth factor, a growth inhibitor, an immunomodulator, a steroid, or an anti-inflammatory; the biodegradable biocompatible polymer comprising one or more residues selected from the group of lactide, glycolide, and caprolactone; the biodegradable biocompatible, polymer exhibiting a mechanical property which enables the cup member to be deformed when contacting a contact surface.
10. The implant device of claim 9 , the biodegradable biocompatible polymer comprising a terpolymer.
11. The implant device of claim 9 , wherein the implant device comprises a pump, pacemaker, defibrillator, or stimulator.