Isotherm-based tissue ablation control system

1. A system for use with at least one cryoprobe for the treatment of biological tissue with thermal ablation, the system comprising:

at least one cryoprobe comprising a distal treatment portion, an exchange chamber in said distal treatment portion, an inflow conduit transporting a cryogen towards said exchange chamber of the distal tissue treatment portion, and an outflow conduit for transporting said cryogen from said exchange chamber of the distal tissue treatment portion;

an inflow temperature sensor at a first location along the inflow conduit and configured to detect an inflow temperature of the cryogen flowing through said inflow conduit at the first location;

an outflow temperature sensor at a second location along the outflow conduit and configured to detect an outflow temperature of the cryogen flowing through said outflow conduit at the second location; and

a processor programmed to

receive procedure data comprising a cryogen flowrate, the inflow temperature and the outflow temperature over time;

calculate a procedure signature based on the cryogen flowrate and a temperature difference between said inflow temperature and said outflow temperature over time;

compare the procedure signature to a planning signature, said planning signature based on previously acquired image data of said tissue; and

adjust power to the at least one cryoprobe based on comparing said procedure signature to said planning signature.

2. The system of claim 1 wherein said planning signature is a planning isotherm volume of tissue and said procedure signature is a tissue volume isotherm obtained during or immediately after the procedure.

3. The system of claim 1 wherein said processor is further programmed to automatically regulate the cryogen flowrate of said cryogen to said at least one cryoprobe.

4. The system of claim 1 wherein said processor is further programmed to automatically regulate the temperature of said cryogen to said at least one cryoprobe.

5. The system of claim 1 wherein said processor is further programmed to determine said planning signature.

6. The system of claim 5 wherein said processor is further programmed to receive manual input.

7. The system of claim 5 wherein said processor is programmed to compute said planning signature based on previously acquired image data of a marker deposited in said tissue.

8. The system of claim 5 wherein said processor is programmed to compute said planning signature based on a presence of a blood vessel in proximity to the tissue.

9. The system of claim 1 wherein said processor is further programmed to calculate the procedure signature based on procedure data comprising live image data.

10. The system of claim 1 further comprising a refrigerator for cooling said cryogen.

11. The system of claim 10 further comprising a cryogen tank, said cryogen tank in fluid communication with said cryoprobe.

12. The system of claim 11 further comprising a pump to drive the cryogen from the cryogen tank and along the inflow conduit and outflow conduit.

13. The system of claim 1 wherein the first location and the second location are within the distal treatment portion of the cryoprobe.

14. The system of claim 13 wherein the cryogen has a freezing point less than −90 degrees C.

15. The system of claim 14 wherein said cryogen is one liquid selected from the group of propane, perfluropropane, Refrigerant 124, and Refrigerant 1270.

16. The system of claim 1 wherein said processor is further programmed to stop treatment if the procedure signature matches the planning signature.

17. The system of claim 1 wherein said processor is further programmed to adjust the cryogen flowrate to force the procedure signature to converge with the planning signature.

18. The system of claim 1 wherein said at least one cryoprobe includes a plurality of cryoprobes.