Methods of treating fibromyalgia syndrome, chronic fatigue syndrome and pain
View Patent ↗The present invention provides a method of treating fibromyalgia syndrome (FMS), chronic fatigue syndrome (CFS), and pain in an animal subject. The method generally involves administering a therapeutically effective amount of a dual serotonin norepinephrine reuptake inhibitor compound or a pharmaceutically acceptable salt thereof, wherein said dual serotonin norepinephrine reuptake inhibitor compound is characterized by a non-tricyclic structure and an equal or greater inhibition of norepinephrine reuptake than serotonin reuptake. In particular, the use of milnacipran to treat FMS, CFS, and pain is disclosed.
1. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof an effective amount of at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.
2. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof a daily dose of about 100 mg of active ingredient, wherein the active ingredient is at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.
3. The method of claim 2 , wherein the active ingredient is in tablet form.
4. The method of claim 2 , wherein the daily dose of active ingredient is divided into multiple doses per day.
5. The method of claim 4 , wherein the daily dose of active ingredient is administered as a 50 mg dose twice per day.
6. A method of treating fibromyalgia, the method consisting essentially of administering to a patient in need thereof a daily dose of about 200 mg of active ingredient, wherein the active ingredient is at least one compound selected from milnacipran, a pharmaceutically acceptable salt of milnacipran, or a combination thereof, with the proviso that the method excludes administering phenylalanine, tyrosine, or tryptophan.
7. The method of claim 6 , wherein the active ingredient is in tablet form.
8. The method of claim 6 , wherein the daily dose of active ingredient is divided into multiple doses per day.
9. The method of claim 8 , wherein the daily dose of active ingredient is administered as a 100 mg dose twice per day.
10. The method of claim 9 , wherein the daily dose of active ingredient is administered as two 50 mg doses in the morning and two 50 mg doses in the evening.