IP Library › Granted Patent US 9,029,530
Granted Patent B2
US 9,029,530 · App. 12/649,094 · Granted May 12, 2015

Detection of oligosaccharides

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Quick Facts
Patent No.
US 9,029,530
App. No.
12/649,094
Granted
May 12, 2015
Kind
B2
Abstract

Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.

Claims (5)

1. A composition comprising an isolated oligosaccharide of the following formula: GlcNS-IdoA2S-GlcNS.

2. The composition of claim 1 , wherein the oligosaccharide present in the composition is less than 70% by weight non-reducing end unsaturated oligosaccharide.

3. The composition of claim 1 , wherein the oligosaccharide present in the composition is less than 50% by weight non-reducing end unsaturated oligosaccharide.

4. The composition of claim 1 , further comprising chromatographic resin.

5. A composition comprising of claim 1 , wherein the oligosaccharide further comprises a detectable label attached to the reducing end thereof, wherein the detectable label is 2 H-2-anthranilic acid, 2 H-2-aminopyridine, 2 H-methyl iodide, 13 C methyl iodide, 2 H-pyridyl amine, 2 H-biotin, an antibody, an affinity label, a radiolabel, a chromophore, or a fluorescent label.

Assignments (1)
SECURITY INTEREST Recorded Apr 27, 2026
From: BIOMARIN PHARMACEUTICAL INC.; AMICUS THERAPEUTICS, INC.
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 075493/0968 →