Endoluminal implantable stent-grafts
View Patent ↗An implantable endoluminal device that is fabricated from materials that present a blood or body fluid and tissue contact surface that has controlled heterogeneities in material constitution. An endoluminal stent-graft and web-stent that is made of an monolithic material deposited into a monolayer and etched into regions of structural members and web regions subtending interstitial regions between the structural members. An endoluminal graft is also provided which is made of a biocompatible metal or metal-like material. The endoluminal stent-graft is characterized by having controlled heterogeneities in the stent material along the blood flow surface of the stent and the method of fabricating the stent using vacuum deposition methods.
1. A method of fabricating an implantable medical device for supporting a physiological vessel, comprising the steps of:
a. depositing an initial thin-film of biocompatible metal or metal-like material exhibiting at least one shape memory or superelastic property;
b. forming from the initial thin-film a plurality of thin-film regions and a plurality of structural support regions bounding the thin-film regions, wherein the thin-film regions have a thickness different from a thickness of the structural support regions and at least one thin-film region is entirely terminally bounded by structural support regions; and
c. etching a plurality of patterned microporous openings passing transversely through, in the thin-film regions.
2. The method of fabricating an implantable medical device according to claim 1 , wherein the initial thin-film of biocompatible metal is fabricated of nitinol.
3. The implantable medical device according to claim 1 , wherein the plurality of thin-film regions and the plurality of structural support regions are both fabricated of nitinol.
4. The method of fabricating an implantable medical device according to claim 1 , wherein the plurality of structural support regions and the plurality of thin-film regions are fabricated of at least one of a metal or metal-like material exhibiting at least one shape memory or superelastic property.
5. The method of fabricating an implantable medical device according to claim 4 , wherein the plurality of structural support regions and plurality of thin-film regions are fabricated of nitinol.
6. The method of fabricating an implantable medical device according to claim 1 , wherein the plurality of patterned microporous openings each have a maximum dimension sufficient to permit cellular migration there through without permitting fluid flow there through.
7. The method of fabricating an implantable medical device according to claim 1 , wherein each of the plurality of patterned microporous openings have a maximum dimension of about 19 μm.
8. The method of fabricating an implantable medical device according to claim 1 , wherein the plurality of structural support regions comprises struts.
9. The method of claim 1 , wherein the forming step of the plurality of thin-film regions and the plurality of structural support regions bounding the thin-film regions further comprises etching.
10. The method of claim 1 , wherein the forming step of the plurality of thin-film regions and a plurality of structural support regions bounding the thin-film regions further comprises a step of forming a tubular member having a plurality of thin-film regions and a plurality of structural support regions bounding the thin-film regions.
11. The method of claim 1 , further comprising depositing a graft member over the plurality of patterned microporous openings.
12. The method of claim 1 , further comprising depositing a graft member over the plurality of structural support regions and attaching the graft member to opposing ends of the thin film.