IP Library Granted Patent US 8,003,371
Granted Patent B2
US 8,003,371 · App. 12/661,393 · Granted Aug 23, 2011

Systems for genome selection

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Quick Facts
Patent No.
US 8,003,371
App. No.
12/661,393
Granted
Aug 23, 2011
Kind
B2
Abstract

Systems, methods, compositions and apparatus relating to genome selection are disclosed.

Claims (69)

1. An apparatus comprising:

one or more at least partially isolated first sources of one or more polar body genomes;

one or more monitoring units operable to detect one or more genetic characteristics of one or more of the one or more polar body genomes; and

one or more controller units operable to separate one or more female germ line genomes at least partially based on the one or more genetic characteristics of one or more of the one or more polar body genomes.

2. The apparatus of claim 1 , wherein the one or more polar body genomes are at least partially isolated from one or more polar bodies.

3. The apparatus of claim 1 , wherein one or more first sources of one or more polar body genomes comprises:

one or more first sources, the one or more first sources positioned to provide the one or more polar body genomes to one or more of one or more first locations, the one or more monitoring units, the one or more controller units, one or more computing units, one or more hybridization units, one or more sequencing units, or one or more amplifying units.

4. The apparatus of claim 1 , wherein the one or more sourcing units further include one or more second sources of one or more of one or more probes or one or more molecular markers.

5. The apparatus of claim 4 , wherein one or more second sources of one or more of one or more probes or one or more molecular markers comprise:

the one or more second sources, the one or more second sources positioned to provide one or more of the one or more probes or the one or more molecular markers to one or more of one or more first locations, the one or more monitoring units, the one or more controller units, one or more computing units, one or more hybridization units, one or more sequencing units, or one or more amplifying units.

6. The apparatus of claim 1 , wherein the one or more sourcing units are further operable to receive one or more inputs.

7. The apparatus of claim 6 , wherein the one or more sourcing units are further operable to receive the one or more inputs, the one or more inputs including one or more of one or more polar body genomes, one or more male haploid genomes, one or more probes, or one or more molecular markers.

8. The apparatus of claim 1 , wherein the one or more sourcing units further include one or more third sources of one or more male haploid genomes.

9. The apparatus of claim 8 , wherein the one or more male haploid genomes are at least partially isolated from one or more of one or more spermatozoa, one or more spermatocytes, or one or more spermatids.

10. The apparatus of claim 8 , wherein the one or more male haploid genomes are part of one or more of one or more spermatozoa, one or more spermatocytes, or one or more spermatids.

11. The apparatus of claim 8 , wherein one or more third sources of one or more male haploid genomes comprises:

one or more third sources, the one or more third sources positioned to provide the one or more male haploid genomes to one or more of one or more first locations, the one or more monitoring units, the one or more controller units, one or more computing units, one or more hybridization units, one or more sequencing units, or one or more amplifying units.

12. The apparatus of claim 1 , wherein the one or more sourcing units further include one or more fourth sources of one or more female germ line genomes.

13. The apparatus of claim 12 , wherein the one or more female germ line genomes are part of one or more of one or more ova, one or more oogonia, one or more polar bodies, or one or more oocytes.

14. The apparatus of claim 12 , wherein one or more fourth sources of one or more female germ line genomes comprises:

one or more fourth sources, the one or more fourth sources positioned to provide the one or more female germ line genomes to one or more of one or more first locations, the one or more monitoring units, the one or more controller units, one or more computing units, one or more hybridization units, one or more sequencing units, or one or more amplifying units.

15. The apparatus of claim 1 , wherein the one or more monitoring units are operable to detect one or more nucleic acid sequences of one or more of the one or more polar body genomes.

16. The apparatus of claim 15 , wherein the one or more monitoring units are operable to detect one or more markers of the one or more nucleic acid sequences of one or more of the one or more polar body genomes.

17. The apparatus of claim 15 , wherein the one or more monitoring units are operable to identify one or more markers of the one or more nucleic acid sequences of one or more of the one or more polar body genomes.

18. The apparatus of claim 15 , wherein the one or more monitoring units are operable to detect one or more probes hybridized to the one or more nucleic acid sequences of one or more of the one or more polar body genomes.

19. The apparatus of claim 15 , wherein the one or more monitoring units are operable to identify one or more probes hybridized to the one or more nucleic acid sequences of one or more of the one or more polar body genomes.

20. The apparatus of claim 1 , wherein the one or more monitoring units are operable to amplify one or more nucleic acid sequences of one or more of the one or more polar body genomes.

21. The apparatus of claim 1 , wherein the one or more monitoring units are operable to sequence one or more nucleic acid sequences of one or more of the one or more polar body genomes.

22. The apparatus of claim 21 , wherein the one or more monitoring units are further operable to co-localize one or more of one or more probes or one or more molecular markers with one or more nucleic acid sequences of the one or more polar body genomes.

23. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to hybridize one or more probes to one or more nucleic acid sequences of the one or more polar body genomes.

24. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to detect one or more genetic characteristics of one or more male haploid genomes.

25. The apparatus of claim 1 , further comprising:

one or more hybridization units operable to co-localize one or more probes with one or more nucleic acids of one or more of the one or more polar body genomes.

26. The apparatus of claim 25 , wherein the one or more hybridization units are operable to co-localize one or more of the one or more probes or one or more molecular markers with one or more nucleic acid sequences of the one or more polar body genomes.

27. The apparatus of claim 25 , wherein the one or more hybridization units are operable to hybridize the one or more probes with one or more nucleic acid sequences of one or more of the one or more polar body genomes.

28. The apparatus of claim 1 , further comprising:

one or more sequencing units operable to sequence one or more nucleic acids of one or more of the one or more polar body genomes.

29. The apparatus of claim 1 , further comprising:

one or more amplification units operable to amplify one or more nucleic acids of one or more of the one or more polar body genomes.

30. The apparatus of claim 1 , further comprising:

one or more computing units operable to determine the one or more genetic characteristics of one or more of the one or more polar body genomes.

31. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine one or more of the one or more female germ line genomes to select at least partially based on the one or more genetic characteristics of one of more of the one or more polar body genomes.

32. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine the one or more female germ line genomes to select at least partially based on a weighted analysis of the one or more genetic characteristics of one of more of the one or more polar body genomes.

33. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine the one or more female germ line genomes to select at least partially based on one or more of one or more target genetic characteristics or one or more reference genetic characteristics.

34. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine the one or more female germ line genomes to select at least partially based on a weighted analysis of one or more of one or more target genetic characteristics or one or more reference genetic characteristics.

35. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine one or more of the one or more female germ line genomes to select at least partially based on one or more genetic characteristics of one or more male haploid genomes.

36. The apparatus of claim 30 , wherein the one or more computing units are further operable to determine one or more of the one or more female germ line genomes to select at least partially based on a weighted analysis of the one or more genetic characteristics of one of more of the one or more male haploid genomes.

37. The apparatus of claim 1 , further comprising:

one or more computing units operable to receive one or more inputs.

38. The apparatus of claim 37 , wherein the one or more inputs include data representative of one or more genetic characteristics of one or more of one of more of the one or more polar body genomes.

39. The apparatus of claim 37 , wherein the one or more inputs include data representative of one or more characteristics of one or more male haploid genomes.

40. The apparatus of claim 37 , wherein the one or more inputs include data representative of one or more of one or more reference genetic characteristics or one or more target genetic characteristics.

41. The apparatus of claim 1 , wherein the one or more controller units are operable to sort the one or more female germ line genomes at least partially based on the one or more genetic characteristics of one of more of the one or more polar body genomes.

42. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more female germ line genomes at least partially based on a weighted combination of the one or more genetic characteristics of one of more of the one or more polar body genomes.

43. The apparatus of claim 1 , wherein the one or more controller units are operable to sort the one or more female germ line genomes at least partially based on a weighted combination of the one or more genetic characteristics of one of more of the one or more polar body genomes.

44. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more female germ line genomes at least partially based on one or more of one or more target genetic characteristics or one or more reference genetic characteristics.

45. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more female germ line genomes at least partially based on a weighted combination of one or more of one or more target genetic characteristics or one or more reference genetic characteristics.

46. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or female germ line genomes at least partially based on one or more genetic characteristics of one or more male haploid genomes.

47. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more female germ line genomes at least partially based on a weighted combination of one or more genetic characteristics of one or more male haploid genomes.

48. An apparatus comprising:

one or more at least partially isolated first sources of one or more polar body genomes;

one or more computing units operable to receive one or more inputs, the one or more inputs including data representative of one or more characteristics of one or more of the one or more polar body genomes; and

one or more controller units operable to separate one or more female germ line genomes at least partially based on the one or more genetic characteristics of one or more of the one or more polar body genomes.

49. An apparatus comprising:

one or more at least partially isolated first sources of one or more polar body genomes;

one or more computing units operable to receive one or more inputs, the one or more inputs including data representative of one or more characteristics of one or more of the one or more polar body genomes; and operable to determine the one or more female germ line genomes to select at least partially based on the one or more genetic characteristics of one or more of the one or more polar body genomes.

50. An apparatus comprising:

one or more characterization units operable to determine one or more genetic characteristics of one or more polar body genomes; and

one or more computing units operable to determine the one or more female germ line genomes to select at least partially based on the one or more genetic characteristics of one or more of the one or more polar body genomes.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2023
From: DEEP SCIENCE LLC
To: ENTERPRISE SCIENCE FUND, LLC
Reel/Frame 064719/0549 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2016
From: THE INVENTION SCIENCE FUND I, LLC
To: DEEP SCIENCE, LLC
Reel/Frame 037540/0314 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 14, 2011
From: SEARETE LLC
To: THE INVENTION SCIENCE FUND I, LLC
Reel/Frame 026590/0400 →