Systems for genome selection
View Patent ↗Systems, methods, compositions and apparatus relating to genome selection are disclosed.
1. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more units for at least partially decondensing the one or more male germ line haploid genomes;
one or more monitors for detecting one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controllers for selecting one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes.
2. The apparatus of claim 1 , wherein the one or more monitoring units are operable to detect one or more probes hybridized to one or more nucleic acid sequences of the one or more male germ line haploid genomes.
3. The apparatus of claim 1 , wherein the one or more monitoring units are operable to identify one or more of one or more probes or one or more molecular markers associated with one or more nucleic acid sequences of the one or more male germ line haploid genomes.
4. The apparatus of claim 1 , wherein the one or more monitoring units are operable to identify one or more probes hybridized to one or more nucleic acid sequences of the one or more male germ line haploid genomes.
5. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to detect one or more genetic characteristics of one or more female germ line genomes, and the one or more monitoring units are operable to detect one or more of one or more probes or one or more molecular markers associated with the one or more nucleic acid sequences of the one or more female germ line genomes.
6. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to detect one or more genetic characteristics of one or more female germ line genomes, and the one or more monitoring units are operable to detect one or more probes hybridized to the one or more nucleic acid sequences of the one or more female germ line genomes.
7. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to detect one or more genetic characteristics of one or more female germ line genomes, and the one or more monitoring units are operable to identify one or more of one or more probes or one or more molecular markers associated with the one or more nucleic acid sequences of the one or more female germ line genomes.
8. The apparatus of claim 1 , wherein the one or more monitoring units are further operable to detect one or more genetic characteristics of one or more female germ line genomes, and the one or more monitoring units are operable to identify one or more probes hybridized to the one or more nucleic acid sequences of the one or more female germ line genomes.
9. The apparatus of claim 1 , further including one or more hybridization units operable to co-localize one or more probes with one or more nucleic acids of one or more female germ line genomes, wherein one or more of the one or more hybridization units are operable to hybridize the one or more probes with one or more of the one or more female germ line genomes.
10. The apparatus of claim 1 , further comprising:
one or more computing units operable to determine the one or more male germ line haploid genomes to select at least partially based on a weighted analysis of one or more of one or more target genetic characteristics or one or more reference genetic characteristics.
11. The apparatus of claim 1 , further comprising:
one or more computing units operable to determine one or more of the one or more male germ line haploid genomes to select at least partially based on a weighted analysis of the one or more genetic characteristics of the one or more female germ line genomes.
12. The apparatus of claim 1 , wherein the one or more controller units are operable to sort the one or more male germ line haploid genomes at least partially based on a weighted combination of the one or more genetic characteristics of the one or more male germ line haploid genomes.
13. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on a weighted combination of one or more of one or more target genetic characteristics or one or more reference genetic characteristics.
14. The apparatus of claim 1 , wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on one or more genetic characteristics of one or more female germ line genomes.
15. The apparatus of claim 1 , wherein the one or more controller units are operable to separate one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more probes hybridized to one or more nucleic acids of the one or more male germ line haploid genomes.
16. The apparatus of claim 1 , wherein the one or more controller units are operable to sort the one or more male germ line haploid genomes at least partially based on the detection of one or more probes hybridized to one or more nucleic acids of the one or more male germ line haploid genomes.
17. The apparatus of claim 1 , wherein the one or more controller units are operable to separate one or more of the one or more male germ line haploid genomes at least partially based on the detection of one or more of one or more probes or one or more molecular markers associated with one or more nucleic acids of the one or more male germ line haploid genomes.
18. The apparatus of claim 1 , wherein the one or more controller units are operable to sort the one or more male germ line haploid genomes at least partially based on the detection of one or more of one or more probes or one or more molecular markers associated with one or more nucleic acids of the one or more male germ line haploid genomes.
19. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
wherein the one or more male germ line haploid genomes are part of one or more of one or more spermatozoa or one or more spermatocytes.
20. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
wherein the one or more male germ line haploid genomes are at least partially isolated from one or more of one or more spermatozoa or one or more spermatocytes.
21. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
further including one or more second sources of one or more of one or more probes or one or more molecular markers, and one or more third sources of one or more female germ line genomes, wherein the one or more female germ line genomes are at least partially isolated from one or more of one or more ova, one or more oogonia, or one or more oocytes.
22. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
further including one or more second sources of one or more of one or more probes or one or more molecular markers, and one or more third sources of one or more female germ line genomes, wherein the one or more female germ line genomes are part of one or more of one or more ova, one or more oogonia, or one or more oocytes.
23. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
wherein the one or more controller units are operable to separate one or more of the one or more male germ line haploid genomes at least partially based on a weighted combination of the one or more genetic characteristics of the one or more male germ line haploid genomes.
24. An apparatus comprising:
one or more at least partially isolated first sources of one or more male germ line haploid genomes, the one or more male germ line haploid genomes at least partially condensed;
one or more first units operable to at least partially decondense the one or more male germ line haploid genomes;
one or more monitoring units operable to detect one or more genetic characteristics of the one or more male germ line haploid genomes; and
one or more controller units operable to select one or more of the one or more male germ line haploid genomes at least partially based on the one or more genetic characteristics of the one or more male germ line haploid genomes;
wherein the one or more controller units are operable to select one or more of the one or more male germ line haploid genomes at least partially based on a weighted combination of one or more genetic characteristics of one or more female germ line genomes.