Biphenylcarboxamide derivatives as hedgehod pathway modulators
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
1. A method of treating a hematological cancer comprising administering to a patient in need thereof a therapeutically effective amount of N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4′-(trifluoromethoxy)biphenyl-3-carboxamide as shown by the below structure
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the cancer is plasma cell neoplasm.
3. The method of claim 1 , wherein the cancer is leukemia.
4. The method of claim 3 , wherein the cancer is childhood leukemia.
5. The method of claim 3 , wherein the cancer is chronic lymphocytic leukemia, acute leukemia or chronic leukemia.
6. The method of claim 1 , wherein the cancer is lymphoma.
7. The method of claim 6 , wherein the cancer is malignant lymphoma.
8. The method of claim 6 , wherein the cancer is Hodgkin's lymphoma.
9. The method of claim 6 , wherein the cancer is non-Hodgkin's lymphoma, stroma dependent lymphoma, lymphomas of lymphocytic and cutaneous origin, B-cell lymphoma, plasmoblastoma, or plasmacytoma.
10. The method of claim 1 , wherein the cancer is multiple myeloma.