Antimicrobial peptide, compositions, and methods of use
View Patent ↗The present invention provides antimicrobial peptides that exhibit a broad range of antimicrobial activity to gram positive and gram negative bacteria, as well as fungi, mold, and virus. The antimicrobial peptide of the invention is a cationic peptide, and may contain an HIV-TAT or reverse HIV-TAT sequence, or derivative thereof. The present invention further provides antimicrobial compositions containing the cationic peptide. Such compositions are especially useful for topical application to the skin, hair, nail, vagina, urethra, ear, oral cavity, nasal passage, respiratory system, opthalmic region, and various mucosal regions. The compositions of the present invention improve the condition and/or appearance of the treated region, and are suited for long-term and/or routine use to, for example, prevent or prevent the recurrence of microbial infection. The present invention further provides kits for use in improving the condition or appearance of skin, nail, or treated area. These kits may facilitate ease of use, long-term storage, and/or efficacy of the compositions.
1. A pharmaceutical composition comprising a cationic peptide, wherein the cationic peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5 and a pharmaceutically or cosmetically acceptable carrier and/or diluent.
2. The composition according to claim 1 , wherein the cationic peptide comprises the amino acid sequence of SEQ ID NO: 3.
3. The composition according to claim 1 , wherein the cationic peptide comprises the amino acid sequence of SEQ ID NO: 4.
4. The composition according to claim 1 , wherein the cationic peptide comprises the amino acid sequence of SEQ ID NO: 5.
5. The composition according to claim 2 , wherein the composition is a topical composition.
6. The composition according to claim 3 , wherein the composition is a topical composition.
7. The composition according to claim 4 , wherein the composition is a topical composition.
8. A kit for administering a composition, the kit comprising
the composition according to claim 2 and
a dispenser.
9. A kit for administering a composition, the kit comprising
the composition according to claim 3 and
a dispenser.
10. A kit for administering a composition, the kit comprising
the composition according to claim 4 and
a dispenser.
11. A kit for administering a composition, the kit comprising
the composition according to claim 5 and
a dispenser.
12. A kit for administering a composition, the kit comprising
the composition according to claim 6 and
a dispenser.
13. A kit for administering a composition, the kit comprising
the composition according to claim 7 and
a dispenser.
14. The composition according to claim 5 , wherein the composition is selected from the group consisting of solid compositions, liquid compositions, solutions, emulsions, microemulsions, suspensions, creams, lotions, gels, powders, and nasal sprays.
15. The composition according to claim 14 , wherein the composition is a solution.
16. The composition according to claim 14 , wherein the composition is a cream.
17. The composition according to claim 14 , wherein the composition is a lotion.
18. The composition according to claim 14 , wherein the composition is a gel.
19. The composition according to claim 14 , wherein the composition is a nasal spray.
20. The composition according to claim 6 , wherein the composition is selected from the group consisting of solid compositions, liquid compositions, solutions, emulsions, microemulsions, suspensions, creams, lotions, gels, powders, and nasal sprays.
21. The composition according to claim 20 , wherein the composition is a solution.
22. The composition according to claim 20 , wherein the composition is a cream.
23. The composition according to claim 20 , wherein the composition is a lotion.
24. The composition according to claim 20 , wherein the composition is a gel.
25. The composition according to claim 20 , wherein the composition is a nasal spray.
26. The composition according to claim 7 , wherein the composition is selected from the group consisting of solid compositions, liquid compositions, solutions, emulsions, microemulsions, suspensions, creams, lotions, gels, powders, and nasal sprays.
27. The composition according to claim 26 , wherein the composition is a solution.
28. The composition according to claim 26 , wherein the composition is a cream.
29. The composition according to claim 26 , wherein the composition is a lotion.
30. The composition according to claim 26 , wherein the composition is a gel.
31. The composition according to claim 26 , wherein the composition is a nasal spray.
32. The composition according to claim 2 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
33. The composition according to claim 3 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
34. The composition according to claim 4 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
35. The composition according to claim 5 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
36. The composition according to claim 6 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
37. The composition according to claim 7 , wherein the composition contains from about 0.01% w/v to about 20% w/v cationic peptide.
38. The kit according to claim 8 , further comprising a component to facilitate application of the composition.
39. The kit according to claim 38 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, and a cotton swab.
40. The kit according to claim 9 , further comprising a component to facilitate application of the composition.
41. The kit according to claim 40 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, and a cotton swab.
42. The kit according to claim 10 , further comprising a component to facilitate application of the composition.
43. The kit according to claim 42 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, and a cotton swab.
44. The kit according to claim 11 , further comprising a component to facilitate application of the composition.
45. The kit according to claim 44 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, and a cotton swab.
46. The kit according to claim 12 , further comprising a component to facilitate application of the composition.
47. The kit according to claim 46 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, or a cotton swab.
48. The kit according to claim 13 , further comprising a component to facilitate application of the composition.
49. The kit according to claim 48 , wherein said component to facilitate application is selected from the group consisting of a brush, a sponge, or a cotton swab.
50. A cationic peptide comprising the amino acid sequence of SEQ ID NO: 3.
51. The cationic peptide according to claim 50 , wherein said peptide consists of the amino acid sequence of SEQ ID NO: 3.
52. A cationic peptide comprising the amino acid sequence of SEQ ID NO: 4.
53. The cationic peptide according to claim 52 , wherein said peptide consists of the amino acid sequence of SEQ ID NO: 4.
54. A cationic peptide comprising the amino acid sequence of SEQ ID NO: 5.
55. The cationic peptide according to claim 54 , wherein said peptide consists of the amino acid sequence of SEQ ID NO: 5.