Granted Patent B2

US 8,242,286 · App. 12/670,010 · Granted Aug 14, 2012

Abstract

Claims (25)

1. The compound of Formula I

or a pharmaceutically acceptable salt thereof.

2. A method of reducing or preventing the synthesis of sebum,comprising administering to mammal in need thereof a therapeutically effective amount of the compound of Formula I

or a pharmaceutical acceptable salt thereof.

3. A method of reducing or preventingthe synthesis of cholesterol esters and wax esters in the sebaceous glands of a mammal, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound of Formula I

or a pharmaceutically acceptable salt thereof.

4. A method of treating acne, comprising administering to a mammal in need thereof a therapeutically effective amount of the compound of Formula I

or a pharmaceutically acceptable salt thereof.

5. The compound (R)-2-(4-(hydroxymethy)phenoxy)-1-(3-(2-(trifluoromethly)phenoxy)pyrrolidin-1-yl)ethanone.

6. The compound 2-(4-hydroxymethyl)phenoxy)-1-(3-(2-trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone.

7. A pharmaceutical composition comprising: the compound (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound; and a pharmaceutically acceptable carrier, vehicle, diluent or excipient.

8. A pharmaceutical composition comprising: the compound (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound; a second therapeutic agent; and a pharmaceutically acceptable carrier, vehicle, diluent or excipient.

9. The composition of claims 7 wherein said composition is suitable for applying to the skin or hair.

10. The composition of claims 7 wherein said composition is suitable for ingestion.

11. A method of treating or alleviating a condition associated with excess sebum production in a mammal in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.

12. A method of treating or alleviating a condition selected front acne, oily skin, oily hair, shiny skin, greasy-looking skin, greasy-looking hair, or seborrheic dermatitis in a mammal in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-2-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.

13. A method of reducing or preventing the activity of stearoyl CoA desaturase in a mammal in need of such treatment comprising administering to said mammal a therapeutically effective amount of (S)-2-(4-(hydroxymethyl)phenoxy)-1-(3-(2-(trifluoromethyl)phenoxy)pyrrolidin-1-yl)ethanone, or a pharmaceutically acceptable salt of said compound, alone or in combination with a second therapeutic agent.

14. A kit comprising a compound according to claim 1 packaged for retail distribution, which advises a consumer how to utilize the compound to alleviate a condition associated with excess sebum production.

15. A kit comprising a compound according to claim 1 packaged for retail distribution, which advises a consumer how to utilize the compound to alleviate a condition selected from acne, oily skin, oily hair, shiny skin, greasy-looking skin, greasy looking hair, seborrheic dermatitis.

16. The method of claim 2 , wherein said mammal is a human.

17. The method of claim 3 , wherein said mammal is a human.

18. The method of claim 4 , wherein said mammal is a human.

19. The method of claim 11 , wherein said mammal is a human.

20. The method of claim 12 , wherein said mammal is a human.

21. The method of claim 13 , wherein said mammal is a human.

Assignments (7)