IP Library › Granted Patent US 8,475,799
Granted Patent B2
US 8,475,799 · App. 12/672,585 · Granted Jul 2, 2013

HIV-1 GP41 neutralization domain and use thereof

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Quick Facts
Patent No.
US 8,475,799
App. No.
12/672,585
Granted
Jul 2, 2013
Kind
B2
Abstract

The invention relates to isolated monoclonal antibodies which specifically bind to the C-terminal heptad repeat region of gp41 (HR2) and neutralize an HIV-1 primary isolate.

Claims (3)

1. An isolated monoclonal antibody which specifically binds an epitope present on a peptide consisting of the sequence Asn-Tyr-Thr-Xaa 1 -Xaa 2 -Ile-Tyr-Xaa 3 -Leu-Xaa 4 -Glu-Xaa 5 -Ser-Gln-Asn-Gln-Gln-Glu-Xaa 6 -Asn-Glu-Xaa 7 (SEQ ID NO:26), wherein Xaa 1 is Asp or Asn; Xaa 2 is Thr or Leu; Xaa 3 is Lys, Arg, or Thr; Xaa 4 is Leu or Ile; Xaa 5 is Lys, Asp, Glu; Xaa 6 is Glu or Lys; and Xaa 7 is Lys or Gln.

2. The isolated monoclonal antibody of claim 1 , wherein said antibody neutralizes at least one HIV-1 primary isolate.

3. The isolated monoclonal antibody of claim 2 , wherein said HIV-1 primary isolate is from clade A, clade B, clade C, clade D, or clade E.

Assignments (3)
CONFIRMATORY LICENSE Recorded Mar 8, 2022
From: RUTGERS, THE STATE UNIV. OF N.J.
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 059198/0094 →
NUNC PRO TUNC ASSIGNMENT Recorded Sep 6, 2013
From: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
To: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Reel/Frame 031152/0452 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2013
From: PINTER, ABRAHAM
To: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
Reel/Frame 030532/0390 →