Quinazolinone derivatives useful as vanilloid antagonists
View Patent ↗There is described a new polymorphic form of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and a method of preparing it.
1. The crystal form B of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile having structural formula I(B);
characterized by an X-ray diffraction pattern having three or more peaks at 2θ values selected from 9.3, 10.6 and 14.4±0.2°2θ.
2. A method of preparing a compound of formula I(B) in crystal form B according to claim 1 which comprises crystallising the compound of formula I(B) from a solution thereof in water and a water miscible organic solvent.
3. A pharmaceutical composition comprising, as active ingredient, an effective amount of the compound of formula 1(B) in crystal form B according to claim 1 , optionally together with a pharmaceutically acceptable carrier.
4. The crystal form B of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile having structural formula I(B) according to claim 1 characterized by an X-ray diffraction pattern having three or more peaks at 2θ values selected from 9.3, 10.6, 14.4, 15.5, 17.9, 19.9, 23.4±0.2°2θ.
5. A pharmaceutical composition comprising, as active ingredient, an effective amount of the compound of formula 1(B) in crystal form B according to claim 4 , optionally together with a pharmaceutically acceptable carrier.