Pirfenidone therapy and inducers of cytochrome P450
View Patent ↗The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
1. A method of administering pirfenidone therapy to a patient in need thereof, wherein said patient is also in need of a strong inducer of CYP1A2 other than cigarette smoke, comprising (a) administering to the patient a therapeutically effective amount of pirfenidone and (b) avoiding concomitant administration of said strong inducer of CYP1A2.
2. The method of claim 1 , wherein the patient has idiopathic pulmonary fibrosis (IPF).
3. The method of claim 1 , wherein the therapeutically effective amount of pirfenidone is a daily dosage of 2400 mg or 2403 mg per day.
4. A method of administering pirfenidone therapy to a patient in need thereof, wherein said patient is receiving a strong inducer of CYP1A2 other than cigarette smoke, comprising (a) first discontinuing administration of the strong inducer of CYP1A2, and then (b) administering to the patient a therapeutically effective amount of pirfenidone.
5. The method of claim 4 , wherein the patient discontinues administration of said strong inducer of CYP1A2 concurrent to administration of pirfenidone.
6. The method of claim 4 , wherein the patient has idiopathic pulmonary fibrosis (IPF).
7. The method of claim 4 , wherein the therapeutically effective amount of pirfenidone is a daily dosage of 2400 mg or 2403 mg per day.
8. A method of increasing the effectiveness of pirfenidone in the treatment of idiopathic pulmonary fibrosis (IPF) in a patient that is receiving a CYP1A2 inducer, comprising discontinuing the CYP1A2 inducer within 4 weeks prior to pirfenidone administration to decrease the levels of CYP1A2 induction, and then administering pirfenidone.
9. The method of claim 8 , wherein the amount of pirfenidone is administered at a daily dosage of 2400 mg or 2403 mg per day.
10. The method of claim 8 , wherein the patient is a current smoker and smoking is discontinued within 4 weeks prior to pirfenidone administration.
11. The method of claim 10 , wherein the pirfenidone is administered at a daily dosage of 2400 mg or 2403 mg per day.