Methods for treating inflammatory disorders using 2,4-pyrimidinediamine compounds
View Patent ↗Methods for treating an inflammatory disorder and for inhibiting the production of IL-23 using 2,4-pyrimidinediamine compounds represented by formula (I):
1. A method for inhibiting the production of IL-23, comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds according to the formula:
wherein X represents (CH 2 ) m , wherein m is an integer from 1 to 5, and wherein one or more CH 2 are optionally replaced with O, S or N(R 0 ), wherein R 0 represents H, C 1 -C 7 alkyl or C 3 -C 8 cycloalkyl;
Y represents N(R 1 ), O or S, wherein R 1 represents H, C 1 -C 7 alkyl or C 3 -C 8 cycloalkyl;
R 11 , R 12 , R 13 , and R 14 each independently represents C 1 -C 7 alkyl;
p represents 0 or 1;
R 2 represents H, C 1 -C 7 alkyl or C 2 -C 8 alkanoyl;
R 3 represents H, halogen, cyano, nitro, (C 1 -C 7 alkoxy)carbonyl, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 alkoxy or C 1 -C 7 haloalkoxy;
R 4 represents H, C 1 -C 7 alkyl or C 2 -C 8 alkanoyl; and
R 5 represents a substituted aryl or heteroaryl.
2. The method of claim 1 , wherein the method further comprises stimulating the production of IL-10 and/or wherein the subject is a human.
3. A method for stimulating production of IL-10, comprising administering to a subject in need thereof a therapeutically effective amount of one or more compounds according to the formula:
wherein X represents (CH 2 ) m , wherein m is an integer from 1 to 5, and wherein one or more CH 2 are optionally replaced with O, S or N(R 0 ), wherein R 0 represents H, C 1 -C 7 alkyl or C 3 -C 8 cycloalkyl;
Y represents N(R 1 ), O or S, wherein R 1 represents H, C 1 -C 7 alkyl or C 3 -C 8 cycloalkyl;
R 11 , R 12 , R 13 , and R 14 each independently represents C 1 -C 7 alkyl;
p represents 0 or 1;
R 2 represents H, C 1 -C 7 alkyl or C 2 -C 8 alkanoyl;
R 3 represents H, halogen, cyano, nitro, (C 1 -C 7 alkoxy)carbonyl, C 1 -C 7 alkyl, C 1 -C 7 haloalkyl, C 1 -C 7 alkoxy or C 1 -C 7 haloalkoxy;
R 4 represents H, C 1 -C 7 alkyl or C 2 -C 8 alkanoyl; and
R 5 represents a substituted aryl or heteroaryl.